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Congratulations to Dr. Chen, Chinpan for his promotion to Research Fellow on May 11th, 2012. (
2012/05/16 ) |
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Congratulations to the following people for winning 2012 First “Research Competition Award for Attending International Conference” (
2012/04/19 ) |
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Chromosome Regions Linked to Kawasaki Disease: Open Door to New Possibilities for Diagnosis and Treatment. (
2012/04/02 ) |
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Congratulations to Dr. Lin, Wen-Chang for his promotion to Research Fellow on March 21th, 2012. (
2012/03/28 ) |
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Congratulations to Dr. Li, Ling-Hui for her promotion to Associate Research Scientist on Feburary 20, 2012. (
2012/02/22 ) |
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Congratulations to Dr. Mei-Shang Ho for receiving the "Award for Outstanding Technological Contribution, Executive Yuan, Taiwan 2011". (
2012/02/14 ) |
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5/21 (Monday) 11:00-12:00 Noon B1C Lecture Room, IBMS
Promiscuous Liaisons: Functional Interactions of Intrinsically Disordered Proteins in Signaling Networks.
Peter Wright, Ph.D. |
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5/22 (Tuesday) 11:00-12:00 Noon B1B Lecture Room, IBMS
Dynamic Nanoscale Organization and Function of Glutamate Receptors in Synapses.
Daniel Choquet, Ph.D. |
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Research Highlight - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - archive |
Dr. Lee, Te-Chang and Dr. Su, Tsann-Long
Oncogene., Apr 23, 2012
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Multidrug-resistant cells overexpressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activity.
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We synthesized several novel bifunctional alkylating derivatives of 3a-aza-cyclopenta[a]indene (BO-1012, BO-1005, BO-1099 and BO-1101) that are potent DNA interstrand crosslinking agents. In in vitro cytotoxicity assay, these compounds were more cytotoxic to multidrug-resistant (MDR) cells, such as KBvin10, KBtax50 and CEM/VBL, than their parental cells. |
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Dr. Chen, Yuan-Tsong and Dr. Wu, Jer-Yuarn
Nat Genet., Mar 25, 2012
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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
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To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. |
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Dr. Tarn, Woan-Yuh
Mol Cell Biol., Apr 9, 2012
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hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.
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The RNA-binding protein hnRNP Q has been implicated in neuronal mRNA metabolism. Here, we show that knockdown of hnRNP Q increased neurite complexity in cultured rat cortical neurons and induced filopodium formation in mouse neuroblastoma cells. Re-expression of hnRNP Q1 in hnRNP Q-depleted cells abrogated the morphological changes of neurites |
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Dr. Lin, Teng-Nan
Mol Neurobiol., Mar 21, 2012
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Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders.
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As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke, has generated substantial public concern. Unfortunately, despite of discoveries of common factors underlying these diseases, few drugs are available to effectively treat these diseases. |
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