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We welcome Dr. Shauh-Der Yeh, Assistant Professor of Institute of Medicine, Taipei Medical University, to join Cancer Division of our institute as a Joint Assistant Research Fellow. (
2009/06/17
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Gene Found to Reduce Invasion of Cancer Cells, May be Useful for Lung Cancer Therapy.
The occurrence of many cancers is closely related to the mutation of a tumor suppressor gene called p53. Normal p53 inhibits cancer cell proliferation and induces cancer cell death. Taiwan researchers have now discovered that normal p53 also reduces the movement of cancer cells to parts of the body distant from the primary cancer, thus reducing the possibility of secondary cancer growth. Their research was published online in the prestigious scientific journal, Nature Cell Biology on May 17. (
2009/05/26
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The application deadline for admission as a graduate student at TIGP has been extended until April 10, 2009. (
2009/03/27
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National Genotyping Center Collaborates in International Study on Genetics-guided Warfarin Dosing
A National Genotyping Center research team led by Director Yuan-Tsong Chen and Dr. Ming Ta Michael Lee, and Dr. Ming-Shien Wen of Chang-Gung Memorial Hospital recently collaborated in a major international study to investigate the influence of genetics on optimum dosage of the widely-used anticoagulant warfarin. Warfarin is used for the prevention of thromboembolism in patients with deep vein thrombosis, atrial fibrillation, or prosthetic heart valve replacement. The international collaboration’s research results are published in an article in the February 19 issue of the highly influential New England Journal of Medicine. (
2009/02/19
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List of Available Positions for 2009 Research and Development Alternative Military Service in IBMS. (Chinese) (
2009/01/21
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Seminars - -- --- - - - - - - - - - - - - - - more  |
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Research Highlight - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - archive |
Dr. Tang, Tang K.
Nat Cell Biol., June 7, 2009
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CPAP is a cell-cycle regulated protein that controls centriole length.
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Centriole duplication involves the growing of a procentriole (progeny centriole) next to the proximal end of each pre-existing centriole (parental centriole). The molecular mechanisms that regulate procentriole elongation remain obscure. We show here that expression of the centriolar protein CPAP (centrosomal P4.1-associated protein) is carefully regulated during the cell cycle, |
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Dr. Lin, Jung-Hsin
Nucleic Acids Research, May 11, 2009
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SLITHER: a web server for generating contiguous conformations of substrate molecules entering into deep active sites of proteins or migrating through channels in membrane transporters.
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Many proteins use a long channel to guide the substrate or ligand molecules into the well-defined active sites for catalytic reactions or for switching molecular states. In addition, substrates of membrane transporters can migrate to another side of cellular compartment by means of certain selective mechanisms |
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Dr. Lim, Carmay
J. Am. Chem. Soc., May 20, 2009
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Determinants of K+ vs Na+ Selectivity in Potassium Channels
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Ion channels, specialized pore-forming proteins, are an indispensable component of the nervous system and play a crucial role in regulating cardiac, skeletal, and smooth muscle contraction. Potassium ion channels, controlling the action potential of a number of excitable cells |
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Dr. Roffler, Steve R.
Clinical Cancer Research, March 24, 2009
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Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses.
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Tumor-localized activation of immune cells by membrane-tethered anti-CD3 antibodies (CD3L) is under investigation to treat poorly immunogenic tumors. Here we sought to elucidate the mechanism of antitumor immunity elicited by CD3L. |
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A nice article about Academia Sinica in Chemical & Engineering News.
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