您的瀏覽器並不支援JavaScript,但影響頁面呈現,您仍可瀏覽本網頁!
ACADEMIA SINICA INSTITUTE OF BIOMEDICAL SCIENCES
中文 | home | sitemap | contact背景圖
背景圖 conferences research divisions graduate programs research highlight 背景圖
seminars awards&news job opportunities research resources
  introduction core facilities funding opportunities  

:::

research divisions
____________________

 

 

Epidemiology & Genetics
Joint
Cross Div.
Cardiovascular Research
Joint
Cross Div.

 

Cell & Developmental Biology/Regenerative Medicine
Joint
Cross Div.
Structural Biology

 

Infectious Disease &
Immunology
Cross Div.

 

Cancer
Joint
Corresponding
Cross Div.
Neuroscience
Corresponding
Cross Div.
Research Scientist
Adjunct / Emeritus
Research Divisions information
Chen, Yuan-Tsong (Y-T)'s picture

Chen, Yuan-Tsong (Y-T)

Distinguished Research Fellow
Academician, Academia Sinica

Specialty:

  1. Human Genetics
  2. Genomic Medicine

M.D., Ph.D. Columbia University

TEL:   02-27899081

FAX:   02-27899085

E-mail:   chen0010@ibms.sinica.edu.tw

PubMed | Recent Publication

Research Description

    Our research interests are in translational research. We aim at translating the promise of genomic medicine into clinical reality.

    Current research projects:
    1. Identification of novel genes/targets associated with adverse drug reaction and some common multi-factorial diseases such as type II diabetes mellitus and bipolar disorder.
    2. Genetics and molecular mechanisms of Stevens-Johnson syndrome, a life-threatening cutaneous adverse drug reaction. We are investigating how the specific HLA allele and the T cell receptor mediating the cell toxicity in causing disseminated keratinocyte death.
    3. Functional characterization of a novel glucose transporter, Glu 10. We recently identified Glu 10 as the mitochondrial transporter for the oxidized form of vitamin C, and showed that, in this capacity, GLUT10 protects cells from oxidative injury. Our studies also provide a mechanism that explains how loss-of-function Glu10 results in arterial abnormalities in arterial tortuosity syndrome.
    4. Improved therapy for Pompe disease, a debilitating, progressive and often fatal myopathy. An enzyme replacement therapy for Pompe disease has dramatically improved the outcome of the disease; however, limitations of the therapy such as neutralizing antibody and variable skeletal response remain a challenge. We are continuing to explore various strategies to improve the therapies.


Selected Recent Publication

  1. Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD & Chen YT: Granulysin is a key meditor for disseminated keratinocyte death in Strvens-Johnson syndrome and toxic epidermal necrolysis. Nature Medicine 2008, 14:1343-1350.
  2. The International Warfarin Pharmacogenetics Consortium: Estimation of the warfarin dose with clinical and pharmacogenetic data. New Engl J Med 2009, 360:753-64.
  3. The HUGO Pan-Asian SNP Consortium: Mapping Human Genetic Diversity in Asia. Science 2009, 326:1541-1545.
  4. Tsai, F.J., Yang, C.F., Chen, C.C., Chuang, L.M., Lu, C.H., Chang, C.T., Wang, T.Y., Chen, R.H., Shiu, C.F., Liu, Y.M., Chang, C.C., Chen, P., Chen, C.H., Fann, C.S.J., Chen, Y.T., Wu, J.Y.. A genome-wide association study identifies susceptibility variants for Type 2 Diabetes in Han Chinese. PLoS Genetics, 6(2): e1000847, 2010.
  5. Lee, M.T.M., Chen, C.H., Lee, C.S., Chen, C.C., Chong, M.Y., Ouyang, W.C., Chiu, N.Y., Chuo,L.J., Chen, C.Y., Tan, H.K.L., Lane, H.Y., Chang, T.J., Lin, C.H.,Jou, S.H., Hou, Y.M., Feng, J., Lai, T.J., Tung, C.L.,Chen, T.J.,Chang, C.J., Lung, F.W., Chen, C.K., Shiah, I.S., Liu, C.Y., Teng, P.R., Chen, K.H.,Shen, L.J., Cheng, C.S., Chang, T.P., Li, C.F., Chou, C.H., Chen, C.Y., Wang, K.H.T., Fann, C.S.J., Wu,J.Y., Chen, Y.T. and Cheng, A.T.A.. Genome-wide association study of bipolar I disorder in the Han Chinese population. Molecular Psychiatry, 1-9, 2010.
  6. Saleem AN, Chen YH, Baek HJ, Hsiao YW, Huang HW, Kao HJ, Liu KM, Shen LF, Song IW, Tu CPD, Wu JY, Kikuchi T, Justice MJ, Yen JJY, Chen YT: Mice with alopecia, osteoporosis and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS Genetics 2010, 6:e1000985.
  7. Lee YC, Huang HY, Chang CJ, Cheng CH and Chen YT: Mitochondrial GLUT 10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insights into arterial tortuosity syndrome. Human Molecular Genetics 2010, 19:3721-3733.
  8. Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Laio HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY, and the Taiwan SJS consortium: HLA-B*1502 screening, Carbamazepine, and preventing Stevens-Johnson Syndrome. New Engl J Med 2011, 364:1126-1133.
  9. Lee, YC, Kuo, HC, Chang, JS, Chang, LY, Huang, LM, Chen, MR, Liang, CD, Chi, H, Huang, FY, Lee, ML, Huang, YC, Hwang, B, Chiu, NC, Hwang, KP, Lee, PC, Chang, LC, Liu, YM, Chen, YJ, Chen, CH, Taiwan Pediatric ID Alliance, Chen, YT, Tsai, FJ, Wu, JY. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nature Genetics 2012, 44(5):522-526.
  10. Wei, CY, Chung, WH, Huang, HW, Chen, YT, Hung, SI. Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. Journal of Allergy and Clinical Immunology 2012, 129: 1562-1569.e5.
  11. Ko, TM and Chen, YT. T-cell receptor and carbamazepine-inducedStevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction. Expert Rev Clin Immunol 2012, 8(5):467-77.
  12. Wei, CY, Lee, MMT, Chen, YT. Pharmacogenomics of adverse drug reactions: implementing personalized medicine. Human Molecular Genetics 2012, 21: R58-R65
  13. Chang, CJ, Kuo, HC, Chang, JS, Lee, JK, Tsai, FJ, Khor, CC, Chang, LC, Chen, SP, Ko, TM, Liu, YM, Chen, YJ, Hong, YM, Jang, GY, Hibberd, ML, Kuijpers, T, Burgner, D, Levin, M, Burns, JC, Davila, S, International Kawasaki Disease Consortium, Korean Kawasaki Disease Genetics Consortium, Taiwan Kawasaki Disease Genetics Consortium, Chen, YT, Chen, CH, Wu, JY, Lee, YC. Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosin kinase (BLK) in disease susceptibility. PLoS ONE, 8(8): e72037. doi: 10.137/journal.pone.0072037, Aug. 2013.
  14. Chen, CH, Lee, CS, Lee, MTM, Ouyang, WC, Chen, CC, Chong, MY, Wu, JY, Tan, HKL, Lee, YC, Chuo, LJ, Chiu, NY, Tsang, HY, Chang, TJ, Lung, FW, Chiu, CH, Chang, CH, Chen, YS, Hou, YM, Chen, CC, Lai, TJ, Tung, CL, Chen, CY, Lane, HY, Su, TP, Feng, J, Lin, JJ, Chang, CJ, Teng, PR, Liu, CY, Chen, CK, Liu, IC, Chen, JJ, Lu, T, Fan, CC, Wu, CK, Li, CF, Wang, KHT, Wu, LSH, Peng, HL, Chang, CP, Lu, LS, Chen, YT, Cheng, ATA for the Taiwan Bipolar Consortium. Variant GADL1 and response to lithium therapy in bipolar disorder. N Engl J Med 2014 Jan; 370: 119-128.