您的瀏覽器並不支援JavaScript,但影響頁面呈現,您仍可瀏覽本網頁!
ACADEMIA SINICA INSTITUTE OF BIOMEDICAL SCIENCES
中文 | home | sitemap | contact背景圖
背景圖 conferences research divisions graduate programs research highlight 背景圖
seminars awards&news job opportunities research resources
  introduction core facilities funding opportunities  

:::

research divisions
____________________

 

 

Epidemiology & Genetics
Joint
Cross Div.
Cardiovascular Disease
Joint
Cross Div.

 

Cell & Developmental Biology/Regenerative Medicine
Joint
Cross Div.
Structural Biology

 

Infectious Disease &
Immunology
Cross Div.

 

Cancer
Joint
Corresponding
Cross Div.
Neuroscience
Corresponding
Cross Div.
Research Scientist
Adjunct / Emeritus
Research Divisions information
Fann, Cathy S.-J.'s picture

Fann, Cathy S.-J.

Research Fellow

Division Coordinator

Specialty:

  1. Genetic Statistics
  2. Genetic Epidemiology

Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
Ph.D. University of Iowa, Iowa City, Iowa, US

TEL:   02-27899144

FAX:   02-27823047

E-mail:   csjfann@ibms.sinica.edu.tw

PubMed | Recent Publication | Personal Homepage


Research Description

    The major research interest of our laboratory is using biostatistical methods in disease gene mapping, comparative genomics, population genetics, and phylogenetic analysis. We develop novel statistical methods/software and apply frequently used analytical tools to locate chromosomal positions of disease susceptibility genes. The ongoing projects are shown below:

    1. Apply statistical methodologies and analytical tools to identify genes that are associated with human complex diseases, such as bipolar disease, diabetes, hypertension, obesity, Graves’ disease, schizophrenia, breast cancer and liver cancer, etc.
    2. Develop statistical methods to study methylation variation either intergroup or interindividual in a single screen.
    3. Develop a new approach to meta-analysis of population heterogeneity in genome-wide association studies.
    4. Develop new statistical methods for rare variant detecting and population-specific investigation.
    5. Develop new statistical methods for multilocus association mapping. These methods mainly use “longest significant run” based on independent data or dependent data assumptions.
    6. Develop new mathematical models to deal with gene-gene interactions and its application on GWA studies.


Selected Recent Publication

  1. Shu-Chen Chang, Chee-Jen Chang*, Yu-Jr Lin, Ie-Bin Lian, Cathy S.J. Fann*. Use of a failure probability constraint to suggest an initial dose in a Phase I cancer clinical trial.. JOURNAL OF FOOD AND DRUG ANALYSIS. , 2014-05.
  2. Lin YC, Hsieh AR, Hsiao CL, Wu SJ, Wang HM, Lian IB, Fann C. Identifying rare and common disease associated variants in genomic data using Parkinson¿s disease as a model.. JOURNAL OF BIOMEDICAL SCIENCE. 21(1), 88, 2014-08.
  3. Chang SW, Fann CS, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh AR, Chien RN, Chu CM, Tai DI.. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.. PLoS One. 9(6), e99724, 2014-06.
  4. Ching-Lin Hsiao, Ai-Ru Hsieh, Ie-Bin Lian, Ying-Chao Lin, Hui-Min Wang, Cathy S.J. Fann. A novel method for identification and quantification of consistently differentially methylated regions.. PLoS One. 9(5), e97513, 2014-05.
  5. Hsieh AR, Chang SW, Chen PL, Chu CC, Hsiao CL, Yang WS, Chang CC, Wu JY, Chen YT, Chang TC, Fann CS. Predicting HLA genotypes using unphased and flanking single-nucleotide polymorphisms in Han Chinese population.. BMC genomics. 15, 81, 2014-01.
  6. Sengupta Chattopadhyay A, Hsiao CL, Chang CC, Lian IeB, Fann CS. Summarizing techniques that combine three non-parametric scores to detect disease-associated 2-way SNP-SNP interactions. Ge. GENE. 533(1), 304-312, 2014-01.
  7. Chang SW, Fann CS, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh AR, Chien RN, Chu CM, Tai DI. A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. PloS one. 9(6), e99724, 2014.
  8. Lin MT, Hsu CL; TAIWAN PEDIATRIC CV GROUP, Chen PL, Yang WS, Wang JK, Fann CS*, Wu MH*. A genome-wide association analysis identifies novel susceptibility loci for coronary arterial lesions in patients with Kawasaki disease. Translational Research 2013 Feb 27. S1931-5244(13)00040-6.
  9. Okada Y, Sim X, Go M, Wu J, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim S, Wong T, Liu J, Young T, Aung T, Seielstad M, Teo Y, Kim Y, Lee J, Han B, Kang D, Chen CH, Tsai F, Chang L, Fann CS, et al.,The KidneyGen Consortium; The CKDGen Consortium, Albrecht E; The GUGC consortium, et al.,: 2012, “Meta-analysis identifies multiple loci associated with kidney function-related traits in ease Asian populations. ”, NATURE GENETICS, 44(8):904-909.
  10. Lin YC, Hsiao CL, Hsieh AR, Lian IB, Fann CS*, 2012, “Using maximal segmental score in genome-wide association studies.”, GENETIC EPIDEMIOLOGY, 36(6), 594-601.
  11. Wang HM, Hsiao CL, Hsieh AR, Lin YC, Fann CS*, 2012, “Constructing endophenotypes of complex diseases using non-negative matrix factorization and adjusted rand index. ”, PLoS One, 7(7), e40996.
  12. Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, Chen CH, Delahanty RJ, Okada Y, Tabara Y, Gu D, Zhu D, Haiman CA, Mo Z, Gao YT, Saw SM, Go MJ, Takeuchi F, Chang LC, Kokubo Y, Liang J, Hao M, Le Marchand L, Zhang Y, Hu Y, Wong TY, Long J, Han BG, Kubo M, Yamamoto K, Su MH, Miki T, Henderson BE, Song H, Tan A, He J, Ng DP, Cai Q, Tsunoda T, Tsai FJ, Iwai N, Chen GK, Shi J, Xu J, Sim X, Xiang YB, Maeda S, Ong RT, Li C, Nakamura Y, Aung T, Kamatani N, Liu JJ, Lu W, Yokota M, Seielstad M, Fann CS, Genetic Investigation of ANthropometric Traits GIANT Consortium, Wu JY, Lee JY, Hu FB, Tanaka T, Tai ES, Shu XO, 2012, “Meta-analysis identifies common variants associated with body mass index in east Asians.”, NATURE GENETICS, 44(3), 307-311.
  13. Wu DB, Chang CJ, Huang YC, Wen YW, Wu CL, Fann CS*, 2012, “Cost-effectiveness analysis of pneumococcal conjugate vaccine in Taiwan: a transmission dynamic modeling approach.”, VALUE IN HEALTH, 15, S15-S19.
  14. Liu CM, Fann CS, Chen CY, Liu YL, Oyang YJ, Yang WC, Chang CC, Wen CC, Chen WJ, Hwang TJ, Hsieh MH, Liu CC, Faraone SV, Tsuang MT, Hwu HG., 2011, “ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function.”, BIOLOGICAL PSYCHIATRY, 70(1), 51-58. (SCI)
  15. Ai-Ru Hsieh, Ching-Lin Hsiao, Su-Wei Chang, Hui-Min Wang, Fann CS*, 2011, “On the use of multifactor dimensionality reduction (MDR) and classification and regression tree (CART) to identify haplotype-haplotype interactions in genetic studies.”, Genomics., 97(2), 77-85.
  16. Chen PL, Fann CS, Chu CC, Chang CC, Chang SW, Hsieh HY, Lin M, Yang WS, Chang TC., 2011, “Comprehensive Genotyping in Two Homogeneous Graves' Disease Samples Reveals Major and Novel HLA Association Alleles.”, PLoS One., 6(1), e16635.
  17. Hsiao CL, Lian IB, Hsieh AR, Fann CS*,: Modeling expression quantitative trait loci in data combining ethnic populations. BMC Bioinformatics. 2010 Feb 27; 11(1):111.