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research divisions
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Epidemiology & Genetics
Joint
Cross Div.
Cardiovascular Research
Joint
Cross Div.

 

Cell & Developmental Biology/Regenerative Medicine
Joint
Cross Div.
Structural Biology

 

Infectious Disease &
Immunology
Cross Div.

 

Cancer
Joint
Corresponding
Cross Div.
Neuroscience
Corresponding
Cross Div.
Research Scientist
Adjunct / Emeritus
Research Divisions information
Lin, Wen-chang's picture

Lin, Wen-chang

Research Fellow

 

Specialty:

  1. Bioinformatics,
  2. Genomic MedicineTumor Biology
  3. MicroRNA Regulation

Ph.D. Case Western Reserve University

TEL:   02-27899148

FAX:   02-27858594

E-mail:   wenlin@ibms.sinica.edu.tw

PubMed | Recent Publication | Personal Homepage


Research Description

    The long-term research goal of our laboratory is to utilize bioinformatic tools/databases in elucidating molecular and cellular aspects of functional transcription elements in human genome and their significance in oncogenesis and tumor progression. These functional transcription elements include traditional protein-coding genes and non-coding ones. Our research efforts are intended to elucidate functions and regulations of these transcription elements using bioinformatics data-mining and molecular experimental approaches. Previously, we have used the dbEST database for the discovery of novel human genes, identification of functional nucleotide polymorphisms (SNPs and InDels). Subsequently, we further discover and interrogate a new wobble-splicing mechanism at exon junctions that results in the generation of InDel variants in protein coding transcripts. In order to interrogate the functional aspects of these elements, we have developed gene oriented ortholog assignment and protein domain ortholog classification algorithms and databases. Recently, we have also emphasized on the discovery of non-coding regulatory microRNAs. A new informatics pipeline is employed to discover and interrogate miRNAs from genomic sequences of viruses, parasites and animals. We have now engaged in the regulation features of human miRNAs in development and oncogenesis. It is of our interests to detect serum miRNAs in human cancer patients as possible tumor biomarkers.


Selected Recent Publication

    1. Kao HW, Chen HC, Kung HJ, and Lin WC: Tyrosine-Kinase Expression Profiles in Human Gastric Cancer Cell Lines and Their Modulations with Retinoic Acids. British Journal of Cancer 2003, 88: 1058-1064.
    2. LeeI Y, Ho JM, Lin WC: An Algorithm for Generating Representative Functional Annotations Based on Gene Ontology. DEXA Workshops 2003: pp.10-15.
    3. Lai CH, Hu LY, and Lin WC: Single Amino-acid InDel Variants Generated by Alternative Tandem Splice-donor and -acceptor Selection.  Biochem. Biophys. Research Communication 2006, 342: 197-205.
    4. Wu CW, Kao HL, Li AFY, Chi CW, and Lin WC: Protein Tyrosine-phosphatase Expression Profiling in Gastric Cancer Tissues. Cancer Letters 2006,242: 95-103.
    5. Li SC, Pan CY, and Lin WC: Bioinformatic Discovery of MicroRNA Precursors from Human ESTs and Introns.  BMC Genomics 2006, 7: 164.
    6. Tsai KW and Lin WC: Quantitative Analysis of Wobble Splicing Indicates It Is Not Tissue Specific.  Genomics 2006, 88: 855-864.
    7. Hu LY, Tepper CG, Lo SH and Lin WC: An Efficient Strategy to Identify Early TPA-responsive Genes during Differentiation of HL-60 Cells.  Gene Expression 2006, 13: 179-189.
    8. Li SC, Tang P and Lin WC: Intronic MicroRNA: Discovery and Biological implications. DNA and Cell Biology 2007, 26: 195-207.
    9. Tsai KW, Tarn WY and Lin WC: Analyzing Wobble Splicing Reveals that BPS-to-NAGNAG Region Contributes to 3`-tandem Acceptor Site Selection. Molecular and Cellular Biology 2007, 27: 5835-5848.
    10. Ho MR, Jang WJ, Chen CH, Ch'ang LY, Lin WC: Designating eukaryotic orthology via processed transcription units. Nucleic Acids Res 2008, 36:3436-3442
    11. Li SC, Shiau CK, Lin WC: Vir-Mir db: prediction of viral microRNA candidate hairpins. Nucleic Acids Res 2008, 36:D184-189
    12. Tsai KW, Kao HW, Chen HC, Chen SJ, Lin WC: Epigenetic control of the expression of a primate-specific microRNA cluster in human cancer cells. Epigenetics 2009, 4:587-592
    13. Li SC, Chan WC, Hu LY, Lai CH, Hsu CN, Lin WC: Identification of homologous microRNAs in 56 animal genomes. Genomics 2010, 96:1-9
    14. Ho MR, Tsai KW, Chen CH, Lin WC: dbDNV: a resource of duplicated gene nucleotide variants in human genome. Nucleic Acids Res 2011, 39:D920-925