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research divisions
____________________

 

 

Epidemiology & Genetics
Joint
Cross Div.
Cardiovascular Disease
Joint
Cross Div.

 

Cell & Developmental Biology/Regenerative Medicine
Joint
Cross Div.
Structural Biology

 

Infectious Disease &
Immunology
Cross Div.

 

Cancer
Joint
Corresponding
Cross Div.
Neuroscience
Corresponding
Cross Div.
Research Scientist
Adjunct / Emeritus
Research Divisions information
Hsieh, Patrick Ching-Ho's picture

Hsieh, Patrick Ching-Ho

Associate Research Fellow

 

Specialty:

  1. Stem cells and regenerative medicine
  2. Nanoscience and nanomedicine
  3. Translational Research

M.D. Kaohsiung Medical College
Ph.D. University of Washington, Seattle (Bioengineering)

TEL:   02-27899170

FAX:   02-27858594

E-mail:   phsieh@ibms.sinica.edu.tw

PubMed | Recent Publication | Personal Homepage


Research Description

    Although the field of cardiac stem cell therapy has significantly advanced over the past years, the premise of regenerating or replacing diseased human myocardium with functional tissue remains unsatisfied. The overall objective of our research is to promote myocardial stem cell therapy through nano-/micro-environmental engineering the intramyocardial stem cell niche for endogenous cardiac stem cells to reactivate, proliferate, differentiate and repopulate the diseased myocardium. Using a cardiac specific inducible Cre-Lox transgenic mouse strain, we have found that an endogenous cardiac stem cell pool may contribute to ~15% of new cardiomyocytes in the peri-infarcted area, saturated as early as within the first 2 weeks after infarction. Accordingly, we focus on (1) animal models to identify the source of this cardiac stem cell pool, and (2) methods to engineer the cardiac nano-/micro-environments for augmenting the regenerative signaling for spontaneous repair. We have employed a team approach which brings together people from a broad variety of backgrounds, including stem cell biology and biochemistry, biophysics and biomechanics, materials science and controlled drug/gene delivery, synthetic and biochemical engineering, and clinical medicine. This combination has allowed us to work together and interact in a way traditionally not available at an individual laboratory or program.


Selected Recent Publication

  1. Chen CH, Chang MY, Wang SS, Hsieh PC*. “Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs.” Am J Physiol Heart Circ Physiol. 2014;306:H1078-1086.
  2. Hsueh YC, Wu JM, Yu CK, Wu KK, Hsieh PC*. “Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells.” EMBO Mol Med. 2014;6:496-503.
  3. Lin YD, Ko MC, Wu ST, Li SF, Hu JF, Lai YJ, Harn HI, Laio IC, Yeh ML, Yeh HI, Tang MJ, Chang KC, Su FC, Wei EI, Lee ST, Chen JH, Hoffman AS, Wu WT, Hsieh PC*. “A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair.” Biomaterials Science 2014;2:567-580.
  4. Lai CY, Wu PR, Roffler SR, Lee ST, Hwang SM, Wang SS, Wang K, Hsieh PC*. "The clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy" Biomacromolecules 2014;15:564-73.
  5. Toh EK, Chang MY, Hsieh PC*. "Functionalized nanoparticles for future cardiovascular medicine." Therapeutic Delivery. 2013;4:1353-1357.
  6. Liao WY, Li HJ, Chang MY, Tang AC, Hoffman AS, Hsieh PC*. “Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice.” Nanoscale. 2013;5:11079-86.
  7. Chang MY, Yang YJ, Chang CH, Tang AC, Liao WY, Cheng FY, Yeh CS, Lai JJ, Stayton PS, Hsieh PC*. “Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction.” J Control Release. 2013;170:287-294.
  8. Chen CH, Wang SS, Wei EI, Chu TU, Hsieh PC*. “Hyaluronan enhances bone marrow cell therapy for myocardial repair after infarction”. Mol Ther. 2013;21:670-679.
  9. Liu YW, Roan JN, Wang SP, Hwang SM, Tsai MS, Chen JH*, Hsieh PC*. “Xenografted human amniotic fluid-derived stem cell as a cell source in therapeutic angiogenesis.”  Int J Cardiol. 2013;168:66-75.
  10. Tang AC, Chang MY, Tang ZC, Li HJ, Hwang GL, Hsieh PC*. “The treatment of acute thromboembolism in mice using heparin-conjugated carbon nanocapsules”. ACS Nano 2012;6:6099-6107.
  11. Lin YD, Luo CY, Hu YN, Yeh ML, Hsueh YC, Tang MJ, Springer ML, Hsieh PC*. “Nanofibrous scaffolds combined with VEGF delivery creates an intramyocardial microenvironment for arteriogenesis and cardiac regeneration.” Sci Transl Med. 2012;4:146ra109.
  12. Tang ZC, Liao WY, Tang AC, Tsai SJ, Hsieh PC*. “The enhancement of endothelial cell therapy for angiogenesis in hindlimb ischemia using hyaluronan.” Biomaterials. 2011; 32:75-86.
  13. Chan SS, Li HJ, Hsueh YC, Lee DS, Chen JH, Hwang SM, Chen CY, Shih E, Hsieh PC*. “Fibroblast growth factor-10 promotes cardiomyocyte differentiation from embryonic and induced pluripotent stem cells.” PLoS ONE. 2010; 5:e14414.
  14. Lin YD, Yeh ML, Yang YJ, Tsai DC, Zhu TY, Shih YY, Chang MY, Liu YW, Tang ACL, Chen TY, Luo CY, Chang KC, Chen JH, Wu HL, Hung TK, Hsieh PC*. “Intramyocardial peptide nanofiber injection improves post-infarction ventricular remodeling and efficacy of bone marrow cell therapy in pigs.” Circulation. 2010;122:S132-S141.
  15. Chan SS, Shueh YZ, Liu YW, Hsieh PC*. “Harnessing endogenous intra- and extra-cardiac stem cells for cardiac regeneration – hope or hype?”. Drug Discovery Today: Therapeutic Strategies. 2009; 6:127-133.
  16. Chan SS, Chen JH, Hwang SM, Wang IJ, Li HJ, Lee RT, Hsieh PC*. “Salvianolic acid B – vitamin C synergy in cardiac differentiation from embryonic stem cells.” Biochem Biophys Res Commun. 2009;387:723-728.
  17. Cheng FY, Wang SP, Su CH, Tsai TL, Wu PC, Shieh DB, Chen JH, Hsieh PC*, Yeh CS*. “Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes.”. Biomaterials. 2008;29:2104-2112.
  18. Hsieh PC, Segers VFM, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins F, Lee RT. “Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury”. Nat Med. 2007;13:970-974.
  19. Engel FB, Hsieh PC, Lee RT, Keating MT.“ FGF1/p38 Inhibitor Therapy Induces Cardiomyocyte Mitosis, Reduces Scarring and Rescues Function after Myocardial Infarction.” Proc Natl Acad Sci U S A. 2006;103:15546-15551.
  20. Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT. “Local Controlled Intramyocardial Delivery of PDGF Improves Post-Infarction Ventricular Function without Pulmonary Toxicity”. Circulation. 2006;114:637-644.
  21. Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. “Local Myocardial IGF-1 Delivery with Biotinylated Peptide Nanofibers Improves Cell Therapy for Myocardial Infarction.” Proc Natl Acad Sci U S A. 2006;103:8155-8160.
  22. Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT. “Controlled Delivery of PDGF-BB for Myocardial Protection Using Injectable Self-Assembling Peptide Nanofibers”. J Clin Invest.2006;116:237-248.
  23. Hsieh PC, Kenagy RG, Mulvihill ER, Jeanette JP, Wang X, Chang CM, Yao Z, Ruzzo WL, Justice S, Hudkins KL, Alpers CE, Berceli S, Clowes AW. “BMP4: Potential Regulator of Shear Stress-Induced Graft Neointimal Atrophy”. J Vasc Surg. 2006;43:150-158.
  24. Hsieh PC, Davis ME, Likowski LK, Lee RT. “Endothelial-Cardiomyocyte Interactions in Cardiac Development and Repair.” Annu Rev Physiol. 2006;68:51-66.
  25. Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT. “Custom Design of the Cardiac Microenvironment with Biomaterials.” Circ Res. 2005;97:8-15.