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Dr. Lee, Te-Chang and Dr. Su, Tsann-Long Oncogene., Apr 23, 2012 ˙Multidrug-resistant cells overexpressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activity. |
 We synthesized several novel bifunctional alkylating derivatives of 3a-aza-cyclopenta[a]indene (BO-1012, BO-1005, BO-1099 and BO-1101) that are potent DNA interstrand crosslinking agents. In in vitro cytotoxicity assay, these compounds were more cytotoxic to multidrug-resistant (MDR) cells, such as KBvin10, KBtax50 and CEM/VBL, than their parental cells.. ........detail |
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Dr. Tarn, Woan-Yuh Mol Cell Biol., Apr 9, 2012 ˙hnRNP Q regulates Cdc42-mediated neuronal morphogenesis. |
 The RNA-binding protein hnRNP Q has been implicated in neuronal mRNA metabolism. Here, we show that knockdown of hnRNP Q increased neurite complexity in cultured rat cortical neurons and induced filopodium formation in mouse neuroblastoma cells. Re-expression of hnRNP Q1 in hnRNP Q-depleted cells abrogated the morphological changes of neurites. ........detail |
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Dr. Chen, Yuan-Tsong and Dr. Wu, Jer-Yuarn Nat Genet., Mar 25, 2012 ˙Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. |
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Dr. Lin, Teng-Nan Mol Neurobiol., Mar 21, 2012 ˙Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders. |
 As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke, has generated substantial public concern. Unfortunately, despite of discoveries of common factors underlying these diseases, few drugs are available to effectively treat these diseases.. ........detail |
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Dr. Yang, Pan-Chyr EMBO Mol Med., Mar 15, 2012 ˙TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. |
 Trop-2, a cell surface glycoprotein, contains both extracellular epidermal growth factor-like and thyroglobulin type-1 repeat domains. Low TROP2 expression was observed in lung adenocarcinoma tissues as compared with their normal counterparts. The lack of expression could be due to either the loss of heterozygosity (LOH) or hypermethylation of the CpG island DNA of TROP2 upstream promoter region as confirmed by . ........detail |
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Dr. Tao, Mi-Hua Molecular Therapy, Feb 14, 2012 ˙Cancer Immunotherapy Using a Membrane-bound Interleukin-12 With B7-1 Transmembrane and Cytoplasmic Domains. |
 Interleukin-12 (IL-12) has potent antitumor activity, but its clinical application is limited by severe systemic toxicity, which might be alleviated by the use of membrane-anchored IL-12. In the present study, a new membrane-bound IL-12 containing murine single-chain IL-12 and B7-1 transmembrane and cytoplasmic domains (scIL-12-B7TM) was constructed and its efficacy in cancer treatment examined and its protective antitumor mechanism investigated.. ........detail |