Dr. Cheng, Ching-Feng 鄭敬楓 博士

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Dr. Cheng, Ching-Feng
鄭敬楓 博士

Joint Appointment Associate Research Fellow
合聘副研究員

  • M.D., Taipei Medical University Postdoctoral Fellow, University of California, San Diego

  • 02-27899135
Specialty:
  • Integrative Physiology
  • Molecular Cardiology

RESEARCH

With the growth of genetic engineering, mice have become common models of human cardiovascular disease and therefore have stimulated the development of techniques to monitor and image the murine cardiovascular system. We had established techniques with cardiac trans-aortic banding, coronary artery ligation, cardiac ischemic reperfusion, and has established the following in vivo analysis in the past several years including surface ECG, echocardiography, wireless radio-telemetry and heart rate variability studies. Through collaboration with colleagues in our Institute, we have worked on several models of cardiovascular diseases (ASIC3, ATF3). In the past two years, we also established reactive oxidative stress (ROS) related animal model on cardiovascular diseases. Here we used carboplatin or gentamicin induced ROS on heart, liver, and kidney respectively, then to elucidate the therapeutic effects using stains (pravastatin, simvastatin) or adiponectin treatment. We specifically explored the therapeutic mechanism related to anti-apoptosis and anti-inflammation, and the possible involvements on HO-1 and PPARα signaling pathways in such diseases. Recently, we are working on the novel molecular mechanism involved in iron overload cardiomyopathy, and elaborate the effect of using adiponectin supplement or thromboxane A2 inhibition for possible therapeutic molecules in the future. 

研究介紹

由於遺傳工程的發展,目前以小鼠之動物模式來探討人類的心血管疾病極為普遍。本實驗室利用心臟之冠狀動脈結紮術,模擬人類的心肌受損,以及心臟與腎臟缺血後再進行灌流受損模式。在過去的幾年中,實驗室已建立了老鼠在in vivo的檢測系統,包含心電圖、心臟超音波、無線遙測發報系統及心率變異性分析等,並且透過所內PI之間的合作進行基因缺失(ASIC3與ATF3)與心腎血管之疾病之研究。我們也建立了氧化自由基(ROS)之動物模式,利用鐵劑、carboplatin等藥物以誘導ROS,然後再利用pravastatin、simvastatin或adiponectin等藥物來檢視治療的效果,由此發現此治療機轉與抗凋亡及抗發炎有相關,並牽涉到HO-1PPAR的訊息傳導路徑。另外,本研究亦有探討TXA2Calcineurin以及NFAT3等基因在心腎血管中所扮演的角色。

HIGHLIGHT 重要成果

CREW PHOTO 成員合照

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