Dr. Fann, Cathy S.-J. 范盛娟 博士

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Dr. Fann, Cathy S.-J.
范盛娟 博士

Research Fellow
研究員
Division Coordinator
  • Division of Biostatistics, Department of Preventive Medicine and Environmental Health,
    Ph.D. University of Iowa, Iowa City, Iowa, US

  • 02-27899144 (Lab) (Room No: 100)
  • 02-27823047 (Fax)
  • Personal Homepage
Specialty:
  • Genetic Statistics
  • Genetic Epidemiology

RESEARCH

The major research interest of our laboratory is using biostatistical methods and bioinformatic tools in disease gene mapping, comparative genomics, population genetics, and phylogenetic analysis. We develop novel statistical methods/software and apply frequently used analytical tools to locate chromosomal positions of disease susceptibility genes.

 

The ongoing projects are shown below:

 

1.Apply statistical methodologies and analytical tools to identify genes that are associated with human complex diseases, such as bipolar disease, diabetes, hypertension, obesity, Graves disease, schizophrenia, breast cancer and liver cancer, etc.

2.Developing a new approach to address population heterogeneity in meta analysis using GWAS data.

3.Developing new statistical methods for rare variant detection and population-specific investigation.

4.Developing new statistical methods for NGS data.

5.Developing new models to deal with gene-gene/gene-environmental interactions and their application on GWA and NGS studies.

研究介紹

本實驗室主要研究方向是發展新的統計方法與軟體為致病基因定位,及尋找族群之間在演化上及遺傳上的差異。目前研究方向為:

 

1.應用統計方法與分析工具尋找與躁鬱症、糖尿病、高血壓、肥胖、葛瑞夫茲氏疾病、精神分裂症、乳癌、肝癌等複雜性疾病相關之致病基因。

2.考慮整合分析中族群的異質性,發展新統計方法於全基因體中致病基因的研究。

3.發展新的稀少變異統計方法,探討在複雜性疾病中所扮演的角色,及考慮在不同族群中的差異研究。

4.發展新的多點相關性方法,藉由結合多點分數統計量與單套基因型分析方法,增加複雜性遺傳疾病致病基因定位的檢測力。

5.發展新的基因交互作用模型,以探討基因交互作用模式於全基因體致病基因定位的可行性。

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