Dr. Chang, Chen 張程 博士

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Dr. Chang, Chen
張程 博士

Adjunct Research Fellow
兼任研究員

Specialty:
  • Functional MRI/S
  • Neuroscience

RESEARCH

My research is primarily focused on the development and application of magnetic resonance imaging and spectroscopy techniques for the understanding of the relationships among structure, function, metabolism and physiology through studies of pathologic brains and tumors. Specifically, goals include: 1) developing and validating the diffusion and perfusion MRI to evaluate the changes in cerebral hemodynamics as a result of brain damage; 2) combining BOLD-, diffusion tensor- and manganese- MRI to study the functional connectivity in rat brains; 3) developing molecular imaging techniques in studying specific biological pathways, and cell and gene therapy; 4) developing in vivo localized 1H NMR spectroscopy to investigate the biochemical and physiological integrity of the brain.

研究介紹

我的主要研究目標在於發展及應用非侵入性之磁振造影及磁振質譜方法,研究各種腦部動物疾病模型與腫瘤的結構、功能、代謝之變化。主要使用之方法可歸類如下:

  1. 利用擴散與灌流磁振造影技術,分析腦部病變所產生之血液流動機能變化。
  2. 利用血氧濃度、擴散張量與錳的磁振造影技術,研究大鼠腦部功能的功能性。
  3. 建立分子影像技術,以利研究細胞、分子間之互動。
  4. 建立生物活體定位化磁振質譜以分析腦部生化訊號是否健全。

HIGHLIGHT 重要成果

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