Dr. Chern, Yijuang 陳儀莊 博士

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Dr. Chern, Yijuang
陳儀莊 博士

Distinguished Research Fellow
特聘研究員

Specialty:
  • Signal Transduction
  • Gene Regulation
  • Neurodegeneration Disease

RESEARCH

My laboratory focuses on three interrelated research projects: (1) functional characterization of the A2A adenosine receptor (A2AR), (2) physiological and pathological analyses of a calcium-inhibitable adenylyl cyclase (AC6) which is coupled to the A2AR, and (3) development of novel therapeutic treatment for Huntington』s disease (HD). A2AR is a major target of caffeine, the most widely used psychoactive substance. Stimulation of the A2AR activates at least two major cellular signaling cascades: adenylyl cyclase/cAMP/protein kinase A- and protein kinase C-mediated pathways. Novel interacting proteins of A2AR may also contribute to the action of A2AR. Given the importance of A2AR, we are actively investigating the regulation and function of A2AR in vivo. Our goal is to develop treatment(s) for neurodegenerative diseases (including HD) based on the functions and pharmacological properties of A2AR. We are also very interested in AC6, a cAMP production enzyme that is coupled to A2AR. Because AC6 has a long and unique N-terminal domain that binds to Snapin (a component of the SNARE complex which mediates neurotransmission and neurite outgrowth), AC6 might play complex roles in regulating calcium-cAMP interactions and neuronal activities. We are currently exploring the pathophysiological role of AC6 in vivo using genetic modified mouse models.

研究介紹

我們有三個研究興趣:(1)腺甘酸A2A受體(A2AR)的功能,(2)第六亞型腺甘酸環化酶(AC6)的生理及病理調控,(3)開發能治療漢丁頓舞蹈症(HD)的新療法。A2AR是咖啡因的主要作用標的。刺激A2AR會活化PKA,PKC和其結合蛋白。我們發現刺激A2AR可治療漢丁頓跳舞症。未來的目標是根據A2AR的藥理特性來開發治療神經退化疾病(包括HD)的藥物。由於AC6在A2AR訊號傳遞中扮演重要角色,我們也積極利用小鼠模型來探索AC6在體內的病理及生理作用。

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