Dr. Huang, Yi-Shuian 黃怡萱 博士

Brand

Dr. Huang, Yi-Shuian
黃怡萱 博士

Associate Research Fellow
長聘副研究員

Specialty:
  • Translational Control
  • Molecular Neuroscience

RESEARCH

In the central nervous system, each neuron receives thousands of synaptic connections from others and modifies the strength of individual synapses independently with varying degrees of stability. This experience-dependent synaptic plasticity underlies the molecular and cellular basis of learning and memory. Accumulating evidence has suggested that regulated translation of localized mRNAs at specific synapses is one of mechanisms that modify long-term plasticity and memory. Several RNA-binding proteins have been implicated in targeting specific mRNAs to dendrites and/ or regulating translation in response to synaptic activity. Among them is CPEB (cytoplasmic polyadenylation element binding protein), which promotes dendritic transport and polyadenylation-induced translation of CPE-containing (UUUUAU or similar) mRNAs. The study of how CPEB functions in neurons suggests a plausible model whereby transport and translation of specific mRNAs can be regulated by their cognate RNA-binding proteins with spatial and temporal precision to influence plasticity at the stimulated synapse, thereby stably modifying only that connection. Thus, the study of RNA-binding proteins in synaptic translational control will help identifying proteins (i.e. molecular molecules of memory) involved in plasticity, learning and memory. The current focus in the lab is to characterize other CPEB family members, CPEBs2-4, in the mammalian neurons.

研究介紹

記憶如何形成和儲存在我們的腦中,是個有趣卻看似抽象的生物問題。隨著日新月異的技術和基因工程動物的發展,我們逐漸開始了解它的分子機制。在動物的中樞神經系統,神經細胞靠著特有的突觸結觸彼此傳遞訊息。每個突觸是個有塑性的訊息收發個體,會隨著所收到的訊息強度和次數而改變自己的結構,功能及數目,因而加強或減弱特定訊息的迴路。這種突觸可塑性是記憶形成的分子機轉。我們已知若要形成長久性的記憶,需要合成新的蛋白來維持突觸的結構改變。所以這些新合成的蛋白質被認為是組成記憶的分子體。細胞常藉由一群會和核醣核酸結合的蛋白(RNA-binding proteins)來選擇性的調控特定RNA的轉譯j及蛋白的產生,因此,我們選擇了CPEB家族蛋白。希望藉由瞭解其在神經中的功能,去找出和記憶有關的蛋白分子體。找出這些分子體能夠進一步幫助我們對記憶的了解。

HIGHLIGHT 重要成果

MORE 更多

CREW PHOTO 成員合照

團體照
Top