Dr. Su, Chun-Kuei 蘇俊魁 博士

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Dr. Su, Chun-Kuei
蘇俊魁 博士

Associate Research Fellow
副研究員

Specialty:
  • Autonomic Neuroscience
  • Electrophysiology

RESEARCH

Sympathetic nerve activities have rhythms. Via these rhythms, sympathetic nerves deliver effective commands to control many visceral organs. My research interest is to understand how the rhythms are generated. A working hypothesis is that the generation of rhythms depends on a synchronous firing between different fibers. To tackle this issue, we establish an oligofiber recording technique, which allow us to simultaneously record several sympathetic fiber activities. An issue arising is when different fibers fire synchronously, their spike potentials tend to overlap with each other and produce complex waveforms. We come up with series of computer programs, as a part of process ‘the subtraction algorithm’ to solve the ‘spike-overlapping’ problems. We can now look into the temporal correlation of firing between different fibers and explore the neuropharmacological mechanisms underlying synchronous firing behaviors. This line of research will help us to understand the information coding pattern of sympathetic commands. In other words, we can begin understanding the language regarding how the sympathetic nerves talk to their target organs.

研究介紹

交感神經活性具有節律。透過這些節律,交感神經傳送有效的指令以控制許多臟器的功能。我的研究興趣是瞭解這些節律活性如何生成。一個假說是節律活性是因不同的交感神經纖維同步放電所造成的。為了研究這個問題,我們建立了少數單根神經纖維電性活動紀錄法。然而這項技術衍生出另一個問題是、當不同神經纖維同步放電時,動作電未位會互相重疊,而產生複合波形。我們進一步發展系列的程式軟體、利用消減演算法解決波形堆疊的問題。我們現在能更為精確的解析神經纖維之間產生動作電位的時序,並且探討其同步放電之藥理機轉。這一系列的研究將有助於我們進一步地瞭解交感神經指令的編碼方式;也就是說、我們能夠開始瞭解交感神經與其調控的臟器之間所使用的語言型式。 

HIGHLIGHT 重要成果

CREW PHOTO 成員合照

團體照