Ph.D., University of California, Los Angeles
Sympathetic nerve activities have rhythms. Via these rhythms, sympathetic nerves deliver effective commands to control many visceral organs. My research interest is to understand how the rhythms are generated. A working hypothesis is that the generation of rhythms depends on a synchronous firing between different fibers. To tackle this issue, we establish an oligofiber recording technique, which allow us to simultaneously record several sympathetic fiber activities. An issue arising is when different fibers fire synchronously, their spike potentials tend to overlap with each other and produce complex waveforms. We come up with series of computer programs, as a part of process ‘the subtraction algorithm’ to solve the ‘spike-overlapping’ problems. We can now look into the temporal correlation of firing between different fibers and explore the neuropharmacological mechanisms underlying synchronous firing behaviors. This line of research will help us to understand the information coding pattern of sympathetic commands. In other words, we can begin understanding the language regarding how the sympathetic nerves talk to their target organs.