Dr. Yang, Shi-Bing 楊世斌 博士

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Dr. Yang, Shi-Bing
楊世斌 博士

Assistant Research Fellow
助研究員

Specialty:
  • Neurophysiology
  • Energy Metabolism
  • Neural circuits

RESEARCH

Hypothalamus is the integrating center for diverse physiological functions, including metabolism, sleep, sexual behaviors, circadian rhythms and endocrine secretion. Malfunctioning of the hypothalamic circuits can lead to a variety of disorders. Our goal is to combine electrophysiology, mouse genetics and in vivo imaging to deconstruct the functional circuits that regulate metabolism and how the circuits respond during the pathophysiological conditions.

Large-scale epidemiology studies and genetic analysis have revealed that many mutations in ion channel genes are associated with human diseases. Combining patch clamp recording with molecular and cell biology, we are investigating the functional pathophysiology of the channelopathies. Currently we are focusing on the ion channel mutations that are associated with diseases of the endocrine and nervous system.

研究介紹

下視丘為調控新陳代謝、睡眠、性行為、日夜節律以及內分泌等基本生理功能的腦區,而下視丘神經迴路或是神經興奮性異常,皆會導致生理或是本能行為上的病變。目前本實驗室利用電生理、小鼠遺傳學以及活體影像術,來建構下視丘神經元調節新陳代謝的功能性迴路,並以此當基礎,進一步探討下視丘神經元功能異常導致代謝疾病的致病機制。

本實驗室另一個研究方向為人類離子通道基因突變的致病機轉。大尺度流行病學以及遺傳學分析找出許多離子通道基因突變跟人類疾病有強烈的關聯性。藉由結合分子生物學、細胞生物學以及膜片鉗技術,我們將進一步探討離子通道基因突變如何造成內分泌以及神經系統方面疾病。

HIGHLIGHT 重要成果