Dr. Pan, Wen-Harn 潘文涵 博士

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Dr. Pan, Wen-Harn
潘文涵 博士

Research Fellow
研究員

Specialty:
  • Cardiovascular Epidemiology
  • Nutrition Survey and Intervention
  • Food Omics Signature

RESEARCH

My laboratory applies prospective cohort and intervention approaches to study etiology of cardiometabolic diseases with focus on genetic and environmental factors. In recent 10 years, we used omics techniques (genomics, transcriptomics and metabolomics) to dissect etiology of hypertension, obesity, and metabolic and inflammatory diseases and established risk assessment and drug response models. We deploy dimension reduction technique to find influential dietary patterns which is then associated with disease and subclinical disorders. In order to contribute to disease prevention, we design and evaluate efficacy of therapeutic diets with multiple beneficial components to lower blood pressure and to control asthma. At the same time, metabolomics and transcriptomics approach are used to characterize plant foods which will then be categorized and used to tailor individualized therapeutic diets.

研究介紹

本研究室主要以前瞻性研究及臨床試驗法,探討心臟血管代謝疾病之成因(遺傳及環境);近年來以體學研究法(基因體、表現體、代謝體學)探討高血壓、肥胖、及代謝與發炎疾病之成因,並將成果運用在疾病風險評估,及藥物治療效果預測上。飲食資料極其複雜且相互相關,我們使用減維度的方法學找出各種飲食型態,探討其和疾病或臨床徵兆的關係。近來致力於設計涉及多種食物類的治療飲食並進行臨床試驗,如:設計並探討適合台灣人的降血壓、氣喘控制飲食。為找到控制發炎性疾病的最佳飲食,更致力於各種植物性食物的代謝體學和轉譯體學研究,擬將各種植物,就其代謝及發炎圖譜加以分類及運用在不同疾病之飲食設計上。

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