Dr. Wu, Jer-Yuarn 鄔哲源 博士

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Dr. Wu, Jer-Yuarn
鄔哲源 博士

Research Fellow
研究員

Specialty:
  • Human Genetics
  • Pharmacogenetics
  • Genome Medicine

RESEARCH

Our lab's research interest is to identify Han Chinese specific susceptibility genes of complex diseases through genome-wide association analysis(GWAS) and further elucidate disease mechanism of those identified genes. Our research interest includes:

 

1. Functional study of PTPRD and SRR which were previously identified to be associated with type 2 diabetes in Han Chinese through previous GWAS approach.

 

2. We identified CD40 and B lymphocyte kinase (BLK) as the susceptibility gene for Kawasaki disease (KD). We are currently:

(1identifying protein and genetic biomarkers for KD using protein biomarkers for early diagnosis, prognosis prediction, and treatment guidance of KD.

(2) identifying susceptibility loci for IVIG-resistant KD patients.

(3) validating the functional role of BLK in the pathogenesis of KD.

(4) characterizing T-cell receptor repertoire of KD patients.

研究介紹

本實驗室的研究主題為藉由全基因體關聯性分析,針對國人之複雜性疾

病,尋找出特有之易感性基因。我們的研究興趣如下:

 

1. 針對先前所發現之第二型糖尿病國人特有之基因:PTPRD及SRR,做功能性分析。

 

2. 在川崎氏症研究方面,找到BLK及CD40為國人川崎氏症易感性基因。之後的研究包括:

(1) 找出敏感性且專一性高之蛋白質及遺傳生物標誌,以供川崎氏症早期診斷、療效預測及治療方法依據

(2) 找出對IVIG治療療效不佳之易感基因

(3) 驗證並釐清BLK在川崎氏症的病理機制

(4) 分析川崎氏症病患T-cell receptor repertoire。

HIGHLIGHT 重要成果

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