The main research focus of our team is (1) human and mouse genetic studies for type 2 diabetes, obesity, and related metabolic traits (2) translational research of type 2 diabetes and obesity. We aimed to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human. We further validated these findings in genetically modified mice model and dissected molecular mechanisms underlying the associations. We are currently trying to develop small-molecules for treatment for type 2 diabetes and obesity. We hope these efforts can be translated to clinical therapy for patients with type 2 diabetes and obesity. Our current research projects include: 1.Genome-wide linkage or association approaches to identify genetic loci for type 2 diabetes, obesity, and related metabolic traits in human using case-control or family design. 2.Generation of transgenic mice to validate our findings from human genetics and to dissect molecular mechanisms. Based on the identified mechanism, we thought to screen small molecules for treatment. 3.Current, we identify possible targets to treat type 2 diabetes and obesity including enzymes involved in aldehydes and prostaglandins metabolism as well as redox control.
我們團隊主要研究興趣為(1)人類與小鼠肥胖與糖尿病(及相關代謝疾病)之遺傳學(2)人類與小鼠肥胖與糖尿病(及相關代謝疾病)之轉譯醫學。我們嘗試以遺傳學方法定位致病基因, 以基因轉殖鼠探討致病基因作用與分子機轉, 進一步篩選小分子藥物, 期望於臨床前動物模式能治療糖尿病與肥胖症, 並進入臨床試驗。 我們團隊的研究計劃包含 1.以家族或病例對照研究定位第二型糖尿病, 肥胖, 相關代謝疾病與致病基因位點 2.以基因轉殖鼠以及細胞膜式, 探討分子機轉, 並篩選可能小分子藥物 3.目前我們發現醛類代謝, 前列腺素代謝, 以及氧化壓力相關酵素為可能治療糖尿病與肥胖之標的