Dr. Liu, Fu-Tong 劉扶東 博士

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Dr. Liu, Fu-Tong
劉扶東 博士

Distinguished Research Fellow and Vice President, Academia Sinica
特聘研究員 兼副院長
Academician, Academia Sinica
中央研究院院士
    • Ph.D. University of Chicago
    • M.D. University of Miami, School of Medicine
  • 02-2652-3056 (Office)
  • ftliu@ibms.sinica.edu.tw
Specialty:
  • Galectins
  • Allergic Inflammation
  • Immune-mediated dermatoses

RESEARCH

Our research is focused on the investigation of the functions of a family of animal lectins, galectins, in inflammation, innate immunity, cancer, and adiposity.  In the area of inflammation, we are studying the roles of galectin-3, -7, and -8 in skin inflammation, by focusing on their regulation of cytokine and chemokine production by keratinocytes.  In the area of innate immunity, we are studying 1) galectin-3’s effect on retrovirus transmission and influenza virus infection and 2) the role of galectin-8 and -9 in host-pathogen interactions in the gastrointestinal track.  In the area of cancer, we are focusing on the role of galectin-3 and -7 in skin cancer.  In the area of adiposity, we are focusing on galectin-12.  We are devoting an effort to studying the intracellular function of galectins through binding to glycans exposed to the cytosol when intracellular organelles are damaged.  We are developing galectin-3 inhibitors for treatment of inflammatory diseases and cancers, and galectin-12 inhibitors to target adipose tissues for the purpose of reducing adiposity.

研究介紹

我們的研究著重於探究動物凝集素成員之一的半乳糖凝集素,在炎症、先天免疫、癌症與肥胖方面的功能。在炎症的領域,我們正在研究的半乳糖凝集素-3、-7和-8在皮膚炎症所扮演的角色,研究重點是角質細胞如何調控細胞因子和趨化因子的生合成。在先天免疫方面,我們正在研究(一)半乳糖凝集素-3對逆轉錄病毒的傳輸和流感病毒的感染和(二)在胃腸道的半乳糖凝集素-8和-9於宿主和病原體之間相互作用所扮演的角色。在癌症方面,我們的研究重點是半乳糖凝集素-3和-7在皮膚癌的角色。在肥胖的領域,我們專注於半乳糖凝集素-12的研究。此外,我們致力於透過研究細胞質內的半乳糖凝集素與暴露在細胞內損壞的胞器上之的糖基結合,來研究半乳糖凝集素的細胞內功能。我們也致力於開發半乳糖凝集素-3的抑製劑,用於炎性疾病和癌症的治療,以及半乳糖凝集素-12的抑製劑,用於針對脂肪組織來達到降低肥胖的目的。

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