Dr. Hwang, Dennis W黃聖言 博士

Brand

Dr. Hwang, Dennis W
黃聖言 博士

Assistant Research Fellow
助研究員

Specialty:

MRI method development

Neuroscience

RESEARCH

Our research focuses on the development of new MRI methods for use in biomedical applications. A newly developed active feedback frequency lock-in imaging method in combination with conventional MRI techniques was used to enhance MRI contrast. The biomedical applications include liver fibrosis, neurodegenerative diseases involving iron accumulation, and tumor detection. To detect neurodegenerative diseases, we will combine optogenetics with functional MRI to label specific brain regions and investigate brain activity. Also, diffusion tensor MRI will be employed to inspect the neuron distribution in the brain. In hepatic fibrosis, the fibrotic stages can be distinguished by dynamics contrast-enhanced MRI (DCE-MRI) and then combined with feedback frequency lock-in imaging to quantify the liver iron content. This new MRI method can be also used for early detection of hepatic cancer.

研究介紹

我們的研究主要發展新的磁共振影像方法研究及其相關生醫應用,方法上利用新發展的主動式回饋射頻場增強磁共振成像配合傳統的磁共振成像技術,針對腦部的神經病變、肝纖維化及與腫瘤的進行偵測。在腦神經病變研究方面,我們將結合光遺傳學與功能性磁共振成像對特定腦區域進行標定活性,並利用擴散張量磁共振成像量測神經的分布狀況,另一方面神經退化疾病通常會與鐵離子的沉積相關,利用主動式回饋射頻場增強磁共振成像將可以把此類的病變部分做對比度增強以達到偵測的目標。在肝纖維化方面,利用動態對比增強共振成像,分辨肝纖維化分期,並結合主動式回饋射頻場增強磁共振成像方法偵測肝臟鐵含量,可對肝贓癌變早期偵測。

HIGHLIGHT 重要成果

MORE 更多