Dr. Shieh, Sheau-Yann 謝小燕 博士

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重要成果


  • CHK2-mediated regulation of PARP1 in oxidative DNA damage response
    Oncogene, Sep 25, 2018
    Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation ......
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  • Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
    PNAS, May 07, 2018
    Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......
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  • Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
    Nucl. Acids Res., Nov 03, 2015
    Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......
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  • Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.
    J Biol Chem., Apr 24, 2014
    Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its import ......
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  • Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.
    PNAS, Mar 26, 2013
    B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic str ......
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