Dr. Yuh-Shan Jou commented that this discovery of PSPC1 is a key regulatory gene for controlling the deterioration and spread of cancer is uncovered by the scientific community. In the future, if scientists can figure out how to inhibit the PSPC1 oncogene, then it will be possible to reduce the growth and spread of cancer cells and contribute to the development of new and more effective cancer drugs.
Short chain fatty acids (SCFAs) are the bacterial fermentation products existed naturally in our body, and recent studies have implicated the importance of type 2 innate lymphoid cells (ILC2s) in the pathobiology of asthma. Here, we demonstrated the SCFA butyrate directly inhibits ILC2 cytokine production, proliferation and GATA3 expression through histone deacetylase inhibition. Further, the systemic and local administration of butyrate can reduce ILC2-induced airway hyperreactivity and type 2 inflammation in murine models of asthma.
Dr. Jer-Yuarn Wu discovered for the first time that loss of GPNMB causes autosomal-recessive amyloidosis cutis dyschromica. This research was published on February 1, 2018 in the American Journal of Human Genetics.
A novel regulation of DNA repair mechanism in neurons
In a research article published in the January 15th of Nature Cell Biology, Dr. Tang K. Tang uncover for the first time the role of Myosin-Va in the initial step of cilium assembly and reveal the underlying mechanism.
The research was published in the journal Nature Communications on October 10th, 2017.