Dr. Wu, Jer-Yuarn

A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

Nature Communications, Sep 12, 2017

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some health ......

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Dr. Pan, Wen-Harn

Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial

The American Journal of Clinical Nutrition, Sep 06, 2017

Background: Stroke is one of the leading causes of mortality and neurologic deficits. Management measures to improve neurologic outcomes are ......

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Dr. Wang, Guey-Shin

CELF1 Mediates Connexin 43 mRNA Degradation in Dilated Cardiomyopathy

Circulation Research, Sep 05, 2017

Rationale: Downregulation of connexin 43 (Cx43), the major cardiac gap junction protein, is often associated with arrhythmia, dilated cardio ......

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Dr. Chau, Lee-Young

Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness

Oncogene, Aug 28, 2017

Overexpression of heme oxygenase-1 (HO-1), an endoplasmic reticulum-anchored enzyme, is observed in many cancers. HO-1 nuclear translocation ......

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Dr. Yan, Yu-Ting

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity

PLoS Genetics, Aug 21, 2017

HSPB7 is a member of the small heat-shock protein (HSPB) family and is expressed in the cardiomyocytes from cardiogenesis onwards. A dramati ......

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Dr. Tang, Tang K.

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

Nature Communications, Aug 15, 2017

Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that ......

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Dr. Chen, Chien-Chang

Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice

Scientific Reports, Aug 08, 2017

Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart failure. Although a number of key regulator ......

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Dr. Hsieh, Patrick Ching-Ho

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis

Scientific reports, Aug 07, 2017

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn−/&minu ......

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Dr. Chern, Yijuang

Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease

Movement disorders, Aug 07, 2017

Background: Disruptions in gamma-aminobutyric (GABA) acid signaling are believed to be involved in Huntington's disease pathogenesis, bu ......

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Dr. Liao, Fang

CCR6 Deficiency Impairs IgA Production and Dysregulates Antimicrobial Peptide Production, Altering the Intestinal Flora

Frontiers in Immunology, Jul 11, 2017

Intestinal immunity exists as a complex relationship among immune cells, epithelial cells, and microbiota. CCR6 and its ligand–CCL20 a ......

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