Dr. Chen, Chinpan

Protein–DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA

Chemical Communications, May 24, 2018

A new antibacterial drug is urgently needed. We employed a protein–DNA complex-guided pharmacophore modeling approach to screen inhibi ......

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Dr. Chern, Yijuang

Microglial Lectins in Health and Neurological Diseases

Frontiers in Molecular Neuroscience, May 14, 2018

Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS ......

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Dr. Lee, Yungling Leo

Genetic Profiles of Transcriptomic Clusters of Childhood Asthma Determine Specific Severe Subtype

Clinical & Experimental Allergy, May 14, 2018

BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epitheliu ......

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Dr. Roffler, Steve R.

Reversible glycosidic switch for secure delivery of molecular nanocargos

Nature Communications, May 10, 2018

Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which ......

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Dr. Shieh, Sheau-Yann

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

PNAS, May 07, 2018

Checkpoint kinase 1 (CHK1), a Ser/Thr protein kinase, is modified by the K63-linked ubiquitin chain in response to genotoxic stress, which p ......

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Dr. Chang, Ya-Jen

IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury

Experimental & Molecular Medicine, Apr 20, 2018

The monolayered intrarenal urothelium covers the renal papilla and ureteropelvic junction (UPJ). In response to increased renal pressure dur ......

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Dr. Shen, Chen-Yang

SUMOylation of XRCC1 activated by poly(ADP-ribosyl)ation regulates DNA repair

Human Molecular Genetics, Apr 16, 2018

XRCC1 is an essential scaffold protein for base excision repair (BER) and helps to maintain genomic stability. XRCC1 has been indicated as a ......

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Dr. Roffler, Steve R.

High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation

Frontiers in Immunology, Apr 09, 2018

How T cell receptors (TCRs) are triggered to start signaling is still not fully understood. It has been proposed that segregation of the lar ......

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Dr. Chern, Yijuang

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Molecular Neurobiology, Apr 04, 2018

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and synaptic dysfunction. Adenosine is ......

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Dr. Chen, Chinpan

Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis

Scientific Reports, Apr 03, 2018

yclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 ......

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