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CURRICULUM VITAE

Personal details:

Name: Dr. Jon D. Wright		Nationality: British
Date of Birth: March 1971		Marital Status: Married

Contact Address:

Institute of Biomedical Sciences
Academia Sinica
Taipei 11529, Taiwan
For phone and fax details please email me at jon _at_ sinica.edu.tw.

Education and current position:

Academia Sinica, Taiwan (1996 - Present)
PhD University of Essex. (1992 - 1995)
BSc University of Keele. (1989 - 1992)

Dr. B. Brooks Lab, NIHLB, NIH, Bethesda, USA (Feb-Apr 2008), temporary placement for CHARMM development.

Institute of Biomedical Sciences, Academia Sinica,

(Aug 2003 - Present) Assistant Reseach Fellow, My research is in the area of protein-DNA interactions and how we can modify the protein to differenciate between different DNA sequences. I also collaborate in a research project to determine the mechanism for IgE and anti-IgE complex formation. I am also very involved in Bioinfomatics projects initiated within the institute and in additional provide support in the basis of calculations and simulations for the experimental work carried out at Academia Sinica.

(Jan 1996 - Jul 2003) Posdoctoral Research Fellow, initially my project was to design and subsequently use computational techniques to produce an inhibitor of IgE's for synthesis and trials. Following successful completion of that project I studied p53 and how it binds to DNA and why its common mutants do not bind to DNA. This also included using molecular docking techniques to discover new lead compounds to rescue the DNA binding affinty of p53 mutants based on my previous p53 work.

University of Essex,

(October 1992 - December 1995) PhD from the Department of Biological and Chemical Sciences. Project: Computer modeling and design of bioreductive anti-cancer drugs.

University of Keele,

II.1 B.Sc. (Joint Honours) Biology and Chemistry. Philosophy subsidiary. Final year research projects in developing vaccines to fish parasites, and computer modeling of CFCs.

Research Articles:

J.J. Wolfe, J.D. Wright, C.A. Reynolds and A.C.G. Saunders, Electrode potentials for bioreductive agents from neural networks. Journal of Anti-Cancer Drug Design (1994), 9, 85-102.

J.D. Wright and C.A. Reynolds, Energetics of reactions involving radical species in solution: calculation of relative electrode potentials for nitroimidazoles using density functional and continuum methods. Int. J. Quant. Chem. (1996), 59, 135-145.

J.D. Wright and C.A. Reynolds, Exploiting the parallelisation inherent in the windowing approach to Monte Carlo energy perturbation calculations. Theochem (1998), 427, 131-135.

J.D. Wright and C. Lim, Prediction of an anti-IgE binding site on IgE. Protein Eng. (1998), 11, 421-427.

K. Lin, J.D. Wright and C. Lim, Long spacers in PROSITE patterns have a concensus backbone motif. J. Mol. Biol. (2000), 299, 539-548.

G.H. Hakimelahi, A.A Moosavi-Movahedi, S-C . Tsay, F-Y Tsai, J.D. Wright, T. Dudev, S Hakimelahi, and C. Lim, Design, Synthesis and SAR of Novel Carbapenem Antibiotics with High Stability to Xanthomonas maltophilia Oxyiminocephalosporinase Type II J. Med. Chem. (2000), 43, 3632-3640.

J.D. Wright and C. Lim, A fast method for predicting amino acid mutations that lead to unfolding. Protein Eng. (2001), 14, 479-486.

J.D. Wright, S. Noskov and C. Lim, Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain. Nucleic Acids Research, (2002) 30, 1563-1574.

S. Noskov, J.D. Wright and C. Lim, Long-Range Effects of Mutating R248 to Q/W in the p53 Core Domain. J. Phys. Chem. B, (2002) 106, 13047-13057.

J.D. Wright and C. Lim, Mechanism of binding loss upon single-point mutation in p53. Journal of Biosciences, (2007) 32, 827-839.

J.D. Wright and C. Lim, Effect of Metal-Binding Site Geometry on Protein Structure, Mobility, and Function. (article under revision 2009)

Y-T. Wang, J.D. Wright, L. Doudeva, H-C. Jhang, C. Lim and H. Yuann, Redesign of high-affinity nonspecific nucleases with altered sequence preference. J. Am. Chem.Soc (2009) 131, 17345-17353.
C-H, Lo, Y-H Chang, J.D. Wright, S-H Chen, D. Kan, C. Lim and P-H Liang, Combined Experimental and Theoretical Study of Long-Range Interactions Modulating Dimerization and Activity of Yeast Geranylgeranyl Diphosphate Synthase. J. Am. Chem.Soc (2009) 131, 4051-4062.

Interviews:

Western researchers reap rich rewards in eastern institutions, Nature 407 (5 Oct 2000), 657-658.

Taiwan: Biotech vision, Nature 421 (6 Feb 2003), 672-673.

Internet Articles:

J.D. Wright Moving scientific work from traditional SGI/IBM machines to Linux. http://www.aboutlinux.com January 2000 (No longer available).

J.D. Wright Moving scientific work from traditional SGI/IBM machines to Linux Part II, the state of Linux at the current time (Jan 2000). http://www.aboutlinux.com January 2000 (No longer available).

J.D. Wright Application of User-Mode-Linux as an augmented internet Firewall. (Aug 2001). http://user-mode-linux.sourceforge.net August 2001.

Research interests:

Applications of computer techniques to problems in biological chemistry and biology, To date applications have used non-local density functional theory, Monte Carlo simulations, homology modeling, molecular dynamics, protein-ligand docking, ab initio and semi-empirical molecular orbital methods, Poisson-Boltzmann methods, neural networks. I have also experience in using methods and databases related to bioinfomatics and cheminfomatics and programming related to the above techniques.

Computer Programming and Systems Management:

I have a large amount of experience with and knowledge of the UNIX operating system, which includes working as a UNIX system manager for workstations, servers and beowulf clusters. Since taking over the day to day running of our machines and our group budget I have designed and installed a 50 cpu Beowulf cluster dedicated in part to parallel molecular modeling. In addition to looking after the research tools for the group I have experience with installing and using the following software: Cadpac, Mopac, Gaussian, Charmm, Amber, Dock, Boss, Gamess-US, Sybyl, Modeller, NWChem, Delphi, UHBD, DB2 and MySQL as well as most common Windows based software.
I have a good programming knowledge of Fortran, Fortran90 and Perl and have implemented a parallel version of a Monte Carlo program. I have written programs for data analysis for Bioinfomatics projects in Perl and utility programs in both Perl and Fortran90 for use within our group and contributed to projects under the GNU banner. Currently I am learning C in order to extend my abilities as a programmer.

Personal Attributes and Career Prospects:

I enjoy challenges particularly problem solving and learning new skills. I am particularly interested in relating research and development to normal everyday life in a career where there is the possibility of furthering my knowledge and bringing the resources used in computational chemistry and biology to a point where it is useful and practical tool for experimental chemists and biologists.

Hobbies and Non Work:

I enjoy playing sports and currently play soccer with a multinational team from Academia Sinica each week. I also play bass guitar and regularly play in the worship band of the church I attend.

Referees:

For referee's details please email me.

Last update: Thu May 8 13:24:13 CST 2008 Comments to: jon _at_ sinica.edu.tw
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