Anti-PEG antibody Literature
Su YC, Chen BM, Chuang KH, Cheng TL, Roffler SR. Sensitive Quantification of PEGylated Compounds by Second-Generation Anti-Poly(ethylene glycol) Monoclonal Antibodies. Bioconjug Chem., 21:1264-70, 2010. (New sensitive anti-PEG sandwhich ELISA)
Chuang
KH,
Wang HE,
Cheng TC,
Tzou SC,
Tseng WL,
Hung WC,
Tai MH,
Chang TK,
Roffler SR,
Cheng TL. Development
of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of
PEGylated probes. J
Nucl Med.,
51:933-41, 2010. (Cloned anti-PEG
antibodies can act as receptors)
Chuang
KH, Tzou SC, Cheng TC, Kao CH, Tseng WL, Shiea J, Liao KW, Wang YM, Chang YC,
Huang BJ, Wu CJ, Chu PY, Roffler SR, Cheng TL.
Measurement of poly(ethylene glycol) by cell-based
anti-poly(ethylene glycol) ELISA.
Anal Chem.
2010 Mar 15;82(6):2355-2362, 2010. (New
way to measure unconjugated PEG in solutions)
Chuang
KH,
Wang HE,
Chen FM,
Tzou SC,
Cheng CM,
Chang YC,
Tseng WL,
Shiea J,
Lin SR,
Wang JY,
Chen BM,
Roffler SR,
Cheng TL.
Endocytosis of PEGylated agents enhances cancer
imaging and anticancer efficacy.
Mol Cancer Ther.
9:1903-1912, 2010. (Membrane
anti-PEG receptors)
Bailon
P, Won CY.
PEG-modified biopharmaceuticals.
Expert Opin Drug Deliv. 2009 Jan;6(1):1-16. (Review)
Ehrlich
GK,
Michel H,
Chokshi HP,
Malick AW. Affinity
purification and characterization of an anti-PEG IgM.
J Mol Recognit.,
22:99-103, 2009. (AGP3
fragmentation and characterization)
CA White, JG Zhang, LA Salamonsen, M Baca, WD Fairlie, D Metcallf, NA Nicola, L Robb and E Dimitriadis. Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantaiation: A nonhormonal contraceptive strategy. PNAS, 104: 19357-19362, 2007.
(Immunohistochemistry of PEG in tissues using E11)
NC Ton, GJM Parker, A Jackson, S Mullamitha, GA Buonaccorsi, C Roberts, Y Watson, K Davies, S Cheung, L Hope, F Power, J Lawrance, J Valle, M Saunders, R Felix, JA Soranson, L Rolfe, K Zinkewich-Peotti and GC Jayson. Phase I evaluation of CDP791, a PEGykated di-Fab' conjugate that binds vascular endothelia growth factor receptor 2. Clin. Cancer Res., 13: 7113-7118, 2007.
(Immunohistochemistry of PEG-drug in tissue using AGP3)
TL Cheng, CM Cheng, BM Chen, DA Tsao, KH Chuang, SW Hsiao, YH Lin and SR Roffler. Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles. Bioconj. Chem. 16:1225-31, 2005.
(ELISA measurement of PEGylated compounds with AGP3 and E11)
NM Tsai, TL Cheng and SR Roffler. Sensitive quantitation of poly(ethylene glycol)-modified proteins. Biotechniques 30: 396-402, 2001.
P Bailon, A Palleroni, CA Schaffer, CL Spence, WJ Fung, JE Porter, GK Ehrlich, W Pan, ZX Xu, MW Modi, A Farid, W Berthold, M Graves. Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C. Bioconjug Chem., 12:195-202., 2001
(AGP3 ELISA used to develop PEGasys)
TL Cheng, BM Chen, JW Chern, MF Wu and SR Roffler. Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy. Bioconj. Chem., 11: 258-266, 2000
(AGP3-mediated clearance of immunoconjugates for ADEPT)
TL Cheng, PY Wu, MF Wu, JW Chern, and SR Roffler. Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM. Bioconj. Chem., 10: 520-528, 1999.
(AGP3-mediated clearance of PEGylated compounds for the circulation)
Purchases can be made by contacting:
Ms. Mei Lee