Tumor Targeting and Prodrug Lab

Cheng TL, Chuang KH, Chen BM, Roffler SR

Analytical Measurement of PEGylated Molecules

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Cheng TC, Roffler SR, Tzou SC, Chuang KH, Su YC, Chuang CH, Kao CH, Chen CS, Harn IH, Liu KY, Cheng TL, Leu YL

An Activity-Based Near-Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues

J Am Chem Soc. 2012 [Epub ahead of print]

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Chuang CH, Chuang KH, Wang HE, Roffler SR, Shiea JT, Tzou SC, Cheng TC, Kao CH, Wu SY, Tseng WL, Cheng CM, Hou MF, Wang JM, Cheng TL

In Vivo Positron Emission Tomography Imaging of Protease Activity by Generation of a Hydrophobic Product from a Noninhibitory Protease Substrate

Clin Cancer Res. 18:238-247, 2012

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J Persson, I Beyer, R Yumul, Z Ki, HP Kiem, S Roffler and A Lieber

Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models

PLoS One 6:e22303, 2011

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KC Chen, SY Wu, YL Leu, ZM Orijovich, BM Chen, HE Wang, TL Cheng and SR Roffler

A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment

Bioconjugate Chem., 22: 938-948, 2011

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Y Liu, S Tuve, J Persson, I Beyer, R Yumel, ZY Li, K Tragoolpua, KE Hellstrom, S Roffler and A Liebe

Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models

Cancer Gene Ther., 18: 407-418, 2011

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PT Huang, KC Chen, ZM Prijovich, TL Cheng, YL Leu, SR Roffler              

Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors

Cancer Gene Ther., 18: 381-389, 2011

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YC Su, BM Chen, KH Chuang, TL Cheng and SR Roffler.

Sensitive quantitation of pegylated proteins and nanoparticles by second generation anti-polyethylene glycol monoclonal antibodies

Bioconjugate Chem., 21: 1264-1267, 2010

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KH Chuang, HE Wang, TC Cheng, SC Tzou, CM Cheng, CH Kao, CH Chuang, WL Tseng, WC Hung, SR Lin, BM Chen, SR Roffler and TL Cheng.

Development of an universal anti-polyethylene glycol reporter gene for non-invasive Imaging of PEGylated probes

J. Nucl. Med., 51: 933-941, 2010

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YC Li_, BM Chen, PC Wu, TL Cheng, LS Kao, MH Tao, A Lieber and SR Roffler.

Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling

J. Immunol.  (Cutting Edge) 184: 5959-5963, 2010

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KH Chuang, HE Wang, FM Chen,  SC Tzou, CM Cheng, YC Chang, WL Tseng, J Shiea, SR Lin, JY Wang, BM Chen, SR Roffler and TL Cheng

Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy

Mol. Cancer Ther., 9: 1903-1912, 2010.

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Chuang KH, Tzou SC, Cheng TC, Kao CH, Tseng WL, Shiea J, Liao KW, Wang YM, Chang YC, Huang BJ, Wu CJ, Chu PY, Roffler SR, Cheng TL.

Measurement of poly(ethylene glycol) by cell-based anti-poly(ethylene glycol) ELISA

Anal Chem., 82:2355-62, 2010

Chang CM, Lo CH, Shih YM, Chen Y, Wu PY, Tsuneyama K, Roffler S, Tao MH.

Treatment of Metastatic Hepatocellular Carcinoma by Adeno-associated Virus Encoding Interleukin-15 Superagonist

Hum Gene Ther., 21: 611-621, 2010.

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Jung T, Castellana D, Klingbeil P, Hernández IC, Vitacolonna M, Orlicky DJ, Roffler SR, Brodt P, Zöller M.

CD44v6 dependence of premetastatic niche preparation by exosomes

Neoplasia 11:1093-105, 2009

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TY Juan, SR Roffler, HS Hou, SM Huang, KC Chen, YL Leu, ZM Prijovich, CP Yu, CC Wu, GH Sun and TL Cha

Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activity

Clinical Cancer Res., 15:4600-4611, 2009

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SC Tzou, S Roffler, KH Chuang, HP Yeh, CH Kao, YC Su, CM Cheng, WL Tseng, J Shiea, KW Cheng, BM Chen, TL Cheng and HE Wang

Micro-PET imaging of β-glucuronidase activity by the hydrophobic conversion of a glucuronide probe

Radiology, 252: 754-762, 200

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SJ Shieh, FC Chou, PN Yu, WC Lin, DM Chang, SR Roffler, HK Sytwu

Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes

J Immunol. 183(4):2277-85, 2009

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S Tuve, Y Liu, K. Tragoolpua, JD Jacobs,  RC Yumul, ZY Li, R Strauss, KE Hellström, ML Disis, S Roffler and A Lieber

In situ adenovirus vaccination engages T effector cells against cancer   

Vaccine 27: 4225-4239, 2009

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ZM Prijovich, KC Chen, SR Roffler

Local enzymatic hydrolysis of an endogenously-generated metabolite can enhance CPT-11 anti-cancer efficacy 

Mol Cancer Ther., 8:940-946, 2009

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CH Lee, YH Chiang, SE Chang, CL Chong, BM Cheng and SR Roffler

Tumor-localized ligation of CD3 and CD28 with systemic regulatory T cell depletion induces potent innate and adaptive antitumor responses

Clin Cancer Res., 15:2756-2766, 2009

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CM Cheng, PY Chu, KH Chuang, SR Roffler, CH Kao, WL Tseng, J Shiea, WD Chang, YC Su, BM Chen, YM Wang and TL Cheng

Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems

Cancer Gene Ther., 16: 83-90, 2009

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KC Chen, CH Wu, CY Chang, WC Lu, Q Tseng, ZM Prijovich, W Schechinger, YC Liaw, YL Leu and SR Roffler

Directed evolution of a lysosomal enzyme with enhanced activity at neutral pH by mammalian cell-surface display

Chem Biol. 15:1277-86, 2008

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H Wang, Y Liu, Z Li, S Tuve, D Stone, O Kalyushniy, D Shayakhmetov, CL Verlinde, T Stehle, J McVey, A Baker, KW Peng, S Roffler, A Lieber

In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46

J Virol., 82: 10567-79, 2008

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TL Cheng and SR Roffler 

Membrane-tethered proteins for basic research, imaging and therapy

Med Res Rev., 28: 885-928, 2008

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CM Cheng, YL Lu, CH Chuang, WC Hung, J Shiea, YC Su, CH Kao, BM Chen, S Roffler, TL Cheng

Tumor-targeting prodrug-activating bacteria for cancer therapy

 Cancer Gene Ther., 15:393-401, 2008

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H Wang, YC Liaw, D Stone, O Kalyuzhniy, I Amiraslanov, S Tuve, CL Verlinde, D Shayakhmetov, T Stehle, S Roffler, A Lieber 

Identification of CD46 Binding Sites within the Adenovirus Serotype 35 Fiber Knob

J Virol., 81:12785-92, 2007

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S Tuve, BM Chen, Y Liu, TL Cheng, P Toure, PS Sow, Q Feng, N Kiviat, S Ni, ZY Li, SR Roffler, A Lieber 
Combination of tumor-site located CTLA-4 blockade and systemic regulatory T cell depletion induces anti-tumor immunity but not autoimmunity

Cancer Res., 67:5929-39, 2007

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P Voln? J Jarjour, S Baxter, RJ Monnat, BL Stoddard, SR Roffler, AM Scharenberg
Flow Cytometric Analysis of DNA Binding and Cleavage by Cell Surface-Displayed Homing Endonucleases
Nucleic Acids Res., 35:2748-58, 2007

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Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Roffler S, Cheng TL
Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored β-glucuronidase
Gene Ther. 14:565-74, 2007

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KC Chen, TL Cheng, YL Leu, ZM Prijovich, CH Chuang, BM Chen and SR Roffler
Membrane-localized activation of glucuronide prodrugs by β-glucuronidase enzymes

Cancer Gene Ther., 14: 187-200, 2007

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ZM Prijovich, YL Leu and SR Roffler
Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin

Cancer Chemother Pharmacol., 60:7-17, 2007

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KH Chuang, CM Cheng, SR Roffler, YL Lu, SR Lin, JY Wang, WS Tzou, YC Su, BM Chen and TL Cheng
Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines
Bioconjugate Chem., 17: 707-714, 2006

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Kiewlich, J Zhang, C Gross, W Xia, B Larsen, RR Cobb, S Biroc, JM Gu, T Sato, DR Light, T Heitner, J Willuda, D Vogel, F Monteclaro, A Citkowicz, SR Roffler, DA Zajchowski
Anti-EphA2 Antibodies Decrease EphA2 Protein Levels in Murine CT26 Colorectal and Human MDA-231 Breast Tumors But Do Not Inhibit Tumor Growth
Neoplasia 8:18-30, 2006

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AB Liu and SR Roffler
Anti-CTLA4 scFv, a single-chain antibody, protects the expression of E. coli β-galactosidase during repeated intramuscular injections in immune-competent mice
Tzu Chi Med J., 18: 259-265, 2006

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SR Roffler, HE Wang, HM Yu, WD Chang,CM Cheng, YL Lu, BM Chen and TL Cheng
A membrane antibody receptor for noninvasive imaging of gene expression
Gene Ther. 13:412-20, 2006

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MH Yu, SR Roffler and BM Chen
Topoisomerase I activity in ovarian cancer is a predictor of sensitivity to topotecan chemotherapy ?an exciting preliminary finding
Taiwan Gynecol. Oncol., 2:14-22, 2005

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TL Cheng, CM Cheng, BM Chen, DA Tsao, KH Chuang, SW Hsiao, YH Lin and SR Roffler
Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles
Bioconj. Chem. 16:1225-31, 2005

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YW Chang, SC Chen, EC Cheng, YP Ko, YR Kao, YC Tsai, SY Chen, YG Tsay, PC Yang, CW Wu and SR Roffler
CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
Int. J Cancer 116:243-52, 2005

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YP Sher, JY Shih, PC Yang, SR Roffler, YW Chu, CW Wu, CL Yu and K. Peck
Prognosis of non-small cell lung cancer patients by detecting circulating cancer cells in the peripheral blood with multiple marker genes
J Clin Oncol., 11:173-9, 2005

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CJ Chang, KF Tai, SR Roffler and LH Hwang
The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors
J Immunol. 173:6025-32, 2004

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TL Cheng, KWLiao, SC Tzou, CM Cheng, BM Chen, SR Roffler
Hapten-directed targeting to single-chain antibody receptors
Cancer Gene Therapy, 11: 380-8, 2004

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AB Liu and SR Roffler
Anti-CTLA4 scFv expressed on cells can prolong the expression of Escherichia. coli. beta-galactosidase in immune-competent mice
Tzu Chi Med J. 16: 25-31, 2004.

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FH Chang, CH Lee, MT Chen, CC Kuo, YL Chiang, CY Hang and SR Roffler
Surfection: a new platform for transfected cell arrays
Nucleic Acids Res., 32:e33, 2004.

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CH Wu, WR Balasubramanian, YP Ko, G Hsu, SE Chang, ZM Prijovich, YC Chao and SR Roffler
Simple mammalian cell production of recombinant proteins
Biotechnol. Appl. Biochem., 2004

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HK Sytwu, WD Lin, SR Roffler, JT Hung, HS Sung, CH Wang, TL Cheng, SC Tsou, SC Hsi, KL Shen 
Anti-4-1BB-based immunotherapy for autoimmune diabetes: Lessons from a transgenic non-obese diabetic (NOD) model.
J. Autoimmunity. 21: 247-54, 2003

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ZM Prijovich, YL Leu and SR Roffler
Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin
Biochem. Pharmacol., 66: 1181-1187, 2003

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KW Liao, BM Chen, TB Liu, SC Tzo, YM Lin, KF Lin, CI Su and SR Roffler
Stable expression of chimeric anti-CD3 receptors on mammalian cells for stimulation of anti-tumor immunity
Cancer Gene Therapy. 10: 779-790, 2003

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CH Lo, SC Lee, PY Wu, WY Pan, J Su, CW Cheng, SR Roffler, BL Chiang, CN Lee, CW Wu and MH Tao
Antitumor and antimetastatic activity of IL-23
J. Immunol. 171: 600-607, 2003

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YR Kao, JY Shih, WC Wen, YP Ko, BM Chen, YL Chan, YW Chu, PC Yang, CW Wu and SR Roffler
Tumor-associated antigen L6 (TAL6) and the invasion of human lung cancer cells
Clin. Cancer Res., 9:2807-2816,2003

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NM Tsai, BM Chen, SL Wei, CW Wu and SR Roffler
Antitumor immunoglobulin M increases lung metastasis in an experimental model of malignant melanoma
Clin. Exp. Metastasis, 20: 103-109, 2003

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KM Bernt, DS Steinwaerder, S Ni, ZY Li, SR Roffler and A Lieber
Enzyme-activated prodrug therapy enhances tumor-specific replication of adenovirus vectors
Cancer Res., 62: 6089-98, 2002

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ZM Prijovich, BM Chen, YL Leu, JW Chern and SR Roffler
Antitumor activity and toxicity of the new glucuronide prodrug 9-aminocamptothecin glucuronide (9ACG) in mice
Br. J. Cancer, 86: 1634-1638, 2002

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BM Chen, TL Cheng, SC Tzou and SR Roffler
Potentiation of antitumor immunity by antibody-directed enzyme prodrug therapy
Int. J. Cancer, 94: 850-858, 2001

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JW Chen, K Peck, TM Hong, SC Yang, YP Sher, JY Shih, R Wu, SR Roffler, CW Wu and PC Yang
Global Analysis of Gene Expression in Invasion by a Lung Cancer Model
Cancer Res., 61: 5223-5230, 2001

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KW Liao, WC Chou, YC Lo and SR Roffler
Design of transgenes for efficient expression of active chimeric Proteins on mammalian cells

Biotechnol Bioeng, 73:313-323, 2001

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NM Tsai, TL Cheng and SR Roffler
Sensitive quantitation of poly(ethylene glycol)-modified proteins
Biotechniques 30: 396-402, 2001

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KW Liao, YW Chang and SR Roffler
Presence of cloning vector sequences in the untranslated region of some genes in Genbank
J. Biomed. Sci. 7: 529-530, 2000

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BM Chen, JY Chen, M Kao, JB Lin, MH Yu and SR Roffler
Elevated topoisomerase I activity in gynecological cancers as a target for chemoradiation therapy
Gynecoligic Oncol. 79: 272-280, 2000

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Cheng TL, Chen BM, Chern JW, Wu MF and Roffler SR
Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy
Bioconj. Chem., 11: 258-266, 2000

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Hou CL, Tang CC, Roffler SR and Tang TK
Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus

Blood, 96: 747-753, 2000

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Liao KW, Lo YC, and Roffler SR
Activation of lymphocytes by anti-CD3 single-chain antibody dimers expressed on the plasma membrane of tumor cells.
Gene Therapy 7: 339-347, 2000

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Leu YL, Roffler SR and Chern JW
Design and synthesis of water-soluble glucuronide analogs of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
J. Med. Chem., 42: 3623-3628, 1999

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Lomasney JW, Cheng HF, Roffler SR and King K
Activation of PLCdelta1 by Ca++-enzyme-phosphatidylserine ternary complex.
J. Biol. Chem., 274: 21995-22001, 1999

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Chou WC, Liao KW, Lo YC, Jiang SY, Yeh MY and Roffler SR
Expression of Chimeric Monomer and Dimer Proteins on the Plasma Membrane of Mammalian Cells.
Biotechnol. Bioeng., 65: 160-169, 1999

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Cheng TL, Chou WC, Chen BM, Chern JW and Roffler SR
Characterization of an antineoplastic glucuronide prodrug.
Biochem. Pharmacol., 58: 325-328, 1999

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Cheng TL, Wu PY, Wu MF, Chern JW, and Roffler SR
Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM.
Bioconj. Chem. 10: 520-528, 1999

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Cheng TL, Wei SL, Chou WC, Chen BM, Wu MF, Liu PW, Chern JW, and Roffler SR
Bystander killing of tumor cells by antibody-targeted enzymatic activation of a glucuronide prodrug.
Br. J. Cancer 79: 1378-1385. 1999

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Shen AY, Chen CP, Roffler SR
A chelating agent possessing cytotoxicity and antimicrobial activity: 7-morpholinomethyl-8-hydroxyquinoline.
Life Sciences 64: 813-825, 1999

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Peck K, Sher YP, Shih JY, Roffler SR, Wu CW, and Yang PC
Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients.
Cancer Res. 58: 2761-2765, 1998

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Chen BM, Chan LY, Wang SM, Wu MF, Chern JW and Roffler SR
Cure of malignant ascites and generation of protective immunity by monoclonal antibody-targeted activation of a glucuronide prodrug in rats.
Int. J. Cancer, 73: 392-402, 1997

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Cheng TL, Chen BM, Chan LY, Wu PW, Chern JW, and Roffler SR
Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs.
Cancer Immun. Immunother., 44: 305-315, 1997

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Jiang SY, Shyu RY, Huang HF, Tang HS, Young TH, Roffler SR, Chiou YS, and Yeh MY
Detection of alphafetoprotein-expressing cells in the blood of patients with hepatoma and hepatitis.
Brit. J. Cancer, 75: 928-933, 1997

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Shyu RY, Jiang SY, Huang SL, Chang TC, Wu, KL, Roffler SR, and Yeh MY
Growth regulation by all-trans-retinoic acid and retinoic acid receptor messanger ribonucleic acids expression in gastric cancer cells.
Eur. J. Cancer 31A: 237-243, 1995

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Shen AY Hwang MH, Roffler SR, and Chen CF
Cytotoxicty and antimicrobial activity of some naphthol derivatives.
Arch. Pharm. (Weinheim) 328: 197-201, 1995

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Roffler SR, Chan J and Yeh MY
Potentiation of radioimmunotherapy by inhibition of topoisomerase I.
Cancer Res., 54: 1276-1285, 1994

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Wang JJ, Roffler SR, Chou HH, Yin FY and Yin CS
Characterization of mullerian inhibiting substance binding on cervical carcinoma cells demonstrated by immunohistochemistry.
Tissue and Cell, 26: 467-476, 1994

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Wang SM, Chern JW, Yeh MY, Ng JC, Tung E, and Roffler SR
Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy.
Cancer Res. 52: 4484-4491, 1992

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Wang JJ, Roffler SR, Yu MH, Cheng CH, Yin CS, and Yeh MY
Characterization of a tumor associated antigen present on human cervical carcinoma cells by lectin binding and electron microscopy.
Histochem. 97: 453-461, 1992

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Yu MH, Roffler SR, Hwang WS, Chen WL and Yeh MY
In vivo localization of human cervical carcinoma xenografts by radiolabeled monoclonal antibody.
Gynecol. Oncol. 47: 93-101, 1992

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Yeh MY, Roffler SR, and Yu MH
Doxorubicin-monoclonal antibody conjugate for therapy of human cervical carcinoma.
Int. J. Cancer 51: 274-282, 1992

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Roffler SR, Wang SM, Chern JW, Yeh MY, and Tung E
Anti-neoplastic glucuronide prodrug treatment of human tumor cells targerted with a monoclonal antibody-enzyme conjugate.
Biochem. Pharmacol., 42: 2062-2065, 1991

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Yu MH, Roffler SR, Liu HS, Yin CS, and Yeh MY
Flow cytometric analysis of monoclonal antibody reactivity and specificity against human cervical carcinoma.
Chinese J. Obstet. Gynaecol., 30: 90-95, 1991

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Roffler SR, Yu MH, Chen BM, Hsu CJ, and Yeh MY
Therapy of human cervical carcinoma with monoclonal antibody - Psuedomonas exotoxin conjugates.
Cancer Res., 51: 4001-4007, 1991

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Roffler SR, Yu MH, Chen MR, Chen SC, Hsu CT, and Yeh MY
New monoclonal antibody against human cervical carcinoma with diagnostic and therapeutic potential.
Chinese J. Microbiol. Immunol. 24: 19-29, 1991

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Roffler SR, Randolph TW, Miller DA, Blanch HW, and Prausnitz JM
Extractive Bioconversions with non-aqueous solvents.
Bioprocess Technol. 11: 133-172, 1991

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Roffler SR, Blanch HW and Wilke CR
Design and mathematical description of differential contactors used in extractive fermentation.
Biotechnol. Bioeng. 32: 192-204, 1988

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Roffler SR, Blanch HW and Wilke CR
In- situ extractive fermentation of acetone and butanol.
Biotechnol. Bioeng. 31: 135-143, 1988

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Roffler SR, Blanch HW and Wilke CR
Extractive fermentation of acetone and butanol: Process design and economic evaluation.
Biotechnol. Progress 3: 131-140, 1987

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Roffler SR, Blanch HW and Wilke CR
In-situ recovery of butanol during fermentation. II. Fed-batch extractive fermentation.
Bioprocess Eng. 2: 181-190, 1987

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Roffler SR, Blanch HW and Wilke CR
In-situ recovery of butanol during fermentation. I. Batch extractive fermentation.
Bioprocess Eng. 2: 1-12, 1986

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Roffler SR, Blanch HW, and Wilke CR
In-situ recovery of fermentation products.
Trends in Biotechnol. 2: 129-136, 1984

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