劉扶東 博士Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice
PNAS, Sep 12, 2011
The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal's ......
陳金榜 博士Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation
Nucl. Acids Res., Sep 08, 2011
Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a h ......
李小媛 博士Laminin-β1 Impairs Spatial Learning through Inhibition of ERK/MAPK and SGK1 Signaling.
Neuropsychopharmacology, Aug 17, 2011
Laminin is a major structural element of the basal lamina consisting of an α-chain, a β-chain, and a γ-chain arranged in a ......
楊泮池 博士The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.
J Clin Invest., Aug 01, 2011
Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if ......
黃太煌 博士Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis
Nucl. Acids Res., Jul 19, 2011
Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least three Myb-like transcriptional factors (tvMyb1, t ......
潘文涵 博士A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes.
Diabetes, Jul 19, 2011
The plasma adiponectin level, a potential upstream and internal facet of metabolic and cardiovascular diseases, has a reasonably high herita ......
陳儀莊 博士Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington』s disease.
JCB, Jul 18, 2011
Adenosine monophosphate–activated protein kinase (AMPK) is a major energy sensor that maintains cellular energy homeostasis. Huntingto ......
鄔哲源 博士Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Nature Genetics, May 15, 2011
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of e ......
施修明 博士Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
Molecular Cell, May 08, 2011
Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......
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