鄔哲源 博士Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans
American Journal of Human Genetics, Jan 11, 2018
Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ......
李德章 博士A Low-Toxicity DNA-Alkylating N-Mustard-Quinoline Conjugate with Preferential Sequence Specificity Exerts Potent Antitumor Activity Against Colorectal Cancer
Neoplasia, Dec 13, 2017
Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ......
施修明 博士Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction
Scientific Reports, Dec 12, 2017
The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
黃怡萱 博士Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival
Cell Reports, Nov 21, 2017
Summary:
Mammalian olfactory bulbs (OBs) require continuous replenishment of interneurons (mainly granule cells [GCs]) to support local cir ......
黃怡萱 博士CPEB2 Activates GRASP1 mRNA Translation and Promotes AMPA Receptor Surface Expression, Long-Term Potentiation, and Memory
Cell Reports, Nov 14, 2017
Summary:
Activity-dependent synthesis of plasticity-related proteins is necessary to sustain long-lasting synaptic modifications and consol ......
鄔哲源 博士A genome-wide association study links small-vessel ischemic stroke to autophagy
Scientific Reports, Nov 09, 2017
Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ......
黃怡萱 博士Decoding hidden messages in neurons: insights from epitranscriptome-controlled and specialized ribosome-controlled translation
Current Opinion in Neurobiology, Nov 07, 2017
Activity-regulated protein synthesis, especially in the restricted synaptic domains, is critical to maintaining connections and communicatio ......
施嘉和 博士Heparin at physiological concentration can enhance PEG-free in vitro infection with human hepatitis B virus
Scientific Reports, Oct 31, 2017
Hepatitis B virus (HBV) is a blood-borne pathogen responsible for chronic hepatitis, cirrhosis, and liver cancer. The mechanism of HBV entry ......
胡哲銘 博士Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection
ACS Applied Materials & Interfaces, Oct 31, 2017
Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ......
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