2017 成果

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羅傅倫 博士
The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering
Frontiers in Immunology Jul 10, 2017

T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The inte ...

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嚴仲陽 博士
Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction
Scientific Reports Jul 04, 2017

JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full ...

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潘文涵 博士
Dietary Pattern Associated with Frailty: Results from Nutrition and Health Survey in Taiwan
Journal of the American Geriatrics Society Jun 12, 2017

Objectives To investigate whether dietary patterns are associated with frailty phenotypes in an elderly Taiwanese population. De ...

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羅傅倫 博士
Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy
Nature Communications Jun 08, 2017

Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal ...

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陳士隆 博士
Hepatitis C virus subverts human choline kinase-α to bridge PI4KIIIα and NS5A and upregulates PI4KIIIα activation, thereby promoting the translocation of the ternary complex to the ER for viral replication
Journal of Virology May 31, 2017

In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein (NS)5A an ...

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陳垣崇 博士
Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver
Scientific Reports May 19, 2017

Palmitoyltransferase (PAT) catalyses protein S-palmitoylation which adds 16-carbon palmitate to specific cysteines and contributes to variou ...

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陳儀莊 博士
Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis
Frontiers in Cellular Neuroscience May 04, 2017

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that is clinically characterized by progressive muscle wea ...

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林小喬 博士
Modeled structural basis for the recognition of α2-3-sialyllactose by soluble Klotho
The FASEB Journal Apr 25, 2017

Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of whic ...

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林文昌 博士
Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer
Oncotarget Apr 07, 2017

Many reports have implicated that microRNAs involve in cancer development and progression, such as miR-155 in breast cancers and miR-196 in ...

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陳金榜 博士
In-depth study of DNA binding of Cys2His2 finger domains in testis zinc-finger protein
PLoS One Apr 06, 2017

Abstract   Previously, we identified that both fingers 1 and 2 in the three Cys2His2 zinc-finger domains (TZD) of testis zinc-fin ...

Years