2018 成果

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李永凌 博士
Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis
International Journal of Obesity Jul 19, 2018

Background/objectives Obesity and asthma are common chronic diseases and have been reported to be mutually causative. We investigated the ...

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林宜玲 博士
Inhibition of Japanese encephalitis virus infection by the host zinc-finger antiviral protein
PLoS pathogens Jul 17, 2018

CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, ...

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吳成文 博士
Upregulation of E3 ubiquitin ligase CBLC enhances EGFR dysregulation and signaling in lung adenocarcinoma
Cancer Research Jun 26, 2018

CBLC (CBL proto-oncogene c) belongs to the CBL protein family which has E3 ubiquitin ligase activity towards activated receptor tyrosine kin ...

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羅傅倫 博士
Transient AID expression for in situ mutagenesis with improved cellular fitness
Scientific Reports Jun 20, 2018

Activation induced cytidine deaminase (AID) in germinal center B cells introduces somatic DNA mutations in transcribed immunoglobulin genes ...

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譚婉玉 博士
DDX3 activates CBC-eIF3-mediated translation of uORF-containing oncogenic mRNAs to promote metastasis in HNSCC
Cancer research Jun 19, 2018

Mutated or dysregulated DDX3 participates in the progression and metastasis of cancer via its multiple roles in regulating gene expression a ...

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林小喬 博士
How First Shell–Second Shell Interactions and Metal Substitution Modulate Protein Function
Inorganic Chemistry Jun 15, 2018

Hydrogen bonds to metal–ligands in proteins play a vital role in biological function. They help to stabilize/protect the metal complex ...

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陳金榜 博士
Protein–DNA complex-guided discovery of the antibacterial lead E1 for restoring the susceptibility of Klebsiella Pneumoniae to polymyxin B by targeting the response regulator PmrA
Chemical Communications May 24, 2018

A new antibacterial drug is urgently needed. We employed a protein–DNA complex-guided pharmacophore modeling approach to screen inhibi ...

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陳儀莊 博士
Microglial Lectins in Health and Neurological Diseases
Frontiers in Molecular Neuroscience May 14, 2018

Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS ...

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李永凌 博士
Genetic Profiles of Transcriptomic Clusters of Childhood Asthma Determine Specific Severe Subtype
Clinical & Experimental Allergy May 14, 2018

BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epitheliu ...

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羅傅倫 博士
Reversible glycosidic switch for secure delivery of molecular nanocargos
Nature Communications May 10, 2018

Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which ...

Years