Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports, Oct 01, 2020
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......
Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant
Colloids and Surfaces B: Biointerfaces, Sep 22, 2020
Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ......
Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain
Annals of the Rheumatic Diseases, Sep 09, 2020
Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ......
Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
Molecular Therapy, Sep 05, 2020
The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......
Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Journal of Biomedical Science, Sep 04, 2020
The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......
FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development
Journal of Investigative Dermatology, Sep 02, 2020
α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ......
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
Nature Communications, Aug 27, 2020
Galectin-9 is a risk factor for inflammatory Crohn’s disease in the gut. Our research reveal glycosylation of lysosomal membrane prote ......
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
Nature Communications, Aug 26, 2020
Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ......
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression
Cell, Jul 09, 2020
Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To ......
CEACAM3 Decreases Asthma Exacerbations and Modulates Respiratory Syncytial Virus Latent Infection in Children
Thorax, Jun 30, 2020
Background: Respiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to ......