林文昌 博士Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset
Scientific Reports, Oct 01, 2020
Abstract
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene trans ......
廖有地 博士Inhibition of bacterial adherence to biomaterials by coating antimicrobial peptides with anionic surfactant
Colloids and Surfaces B: Biointerfaces, Sep 22, 2020
Abstract
Medical devices are widely used in modern medicine, but their utilities are often limited by the biofilm formation of bacteria ......
陳志成 博士Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain
Annals of the Rheumatic Diseases, Sep 09, 2020
Abstract
Objectives: Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known tri ......
李小媛 博士Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation
Molecular Therapy, Sep 05, 2020
The amyloid precursor protein (APP) intracellular domain (AICD) is implicated in the pathogenesis of Alzheimer’s disease (AD), but pos ......
謝清河 博士Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines - lessons from establishing the Taiwan human disease iPSC Consortium Bank
Journal of Biomedical Science, Sep 04, 2020
Abstract
Background
The Taiwan Human Disease iPSC Service Consortium was established to accelerate Taiwan’s growing stem cell ......
李永凌 博士FUT8 remodeling of EGFR regulates epidermal keratinocyte proliferation during psoriasis development
Journal of Investigative Dermatology, Sep 02, 2020
Abstract
α-(1,6)-fucosyltransferase (FUT8) is implicated in the pathogenesis of several malignancies, but its role in psoriasis i ......
徐志文 博士Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
Nature Communications, Aug 27, 2020
Galectin-9 is a risk factor for inflammatory Crohn’s disease in the gut. Our research reveal glycosylation of lysosomal membrane prote ......
楊鎧鍵 博士Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
Nature Communications, Aug 26, 2020
Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There is a clear need to identify novel mediators ......
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