2022 成果

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唐堂 博士
Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein
Frontiers in Cell and Developmental Biology Mar 02, 2022

      The centrosome is composed of a pair of centrioles and serves as the major microtubule-organizing center (MTOC ...

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楊泮池 博士
Metasurface-Based Abrupt Autofocusing Beam for Biomedical Applications
Small Methods Feb 24, 2022

      Manipulation and precise delivery of optical energies in the regions of interest within specimens require diff ...

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楊泮池 博士
A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant
EMBO Molecular Medicine Feb 21, 2022

      The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has altered the traject ...

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廖有地 博士
The lipid components of high-density lipoproteins (HDL) are essential for the binding and transportation of antimicrobial peptides in human serum
Scientific Reports Feb 16, 2022

    Antimicrobial peptides (AMPs) have been developed for the treatment of bacterial infections, but their applications are ...

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徐志文 博士
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence
Nature Communications Feb 15, 2022

A novel IL-18-mediated anti-bacterial circuit to enforce intestinal host defence and immunity Together with inflammatory IL-1b, IL-18 is ...

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林小喬 博士
PPI-Hotspot DB: Database of Protein-Protein Interaction Hot Spots
Journal of Chemical Information and Modeling Feb 11, 2022

Single-point mutations of certain residues (so-called hot spots) impair/disrupt protein-protein interactions (PPIs), leading to pathogenesis ...

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楊鎧鍵 博士
Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo
Science Advances Jan 21, 2022

      Although atherosclerosis preferentially develops at arterial curvatures and bifurcations where disturbed flow ...

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沈志陽 博士
Genome-wide association study identifies genetic risk loci for adiposity in a Taiwanese population
PLOS Genetics Jan 20, 2022

  Overweight and obese are risk factors for various diseases. In Taiwan, the combined prevalence of overweight and obesity has incre ...

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沈志陽 博士
A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4
npj Genomic Medicine Jan 19, 2022

      Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic loci comm ...

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羅傅倫 博士
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
Communications Biology Jan 11, 2022

      T cells are critically important for host defense against infections. T cell activation is specific because si ...

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