2024 成果

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李小媛 博士
Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2
Cellular and Molecular Life Sciences Jun 20, 2024

Long-term memory formation requires de novo RNA and protein synthesis. Using differential display PCR, we found that the NCoR1 cDN ...

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楊瑞彬 博士
SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation
Cardiovascular Research Jun 13, 2024

Aims: SCUBE2 (Signal peptide-CUB-epidermal growth factor-like domain-containing protein 2) is a secreted or membrane-bound protein orig ...

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蔡松智 博士
Epitranscriptomic cytidine methylation of the hepatitis B viral RNA is essential for viral reverse transcription and particle production
PNAS Jun 03, 2024

Epitranscriptomic RNA modifications have emerged as important regulators of the fate and function of viral RNAs. One prominent modification, ...

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林文昌 博士
Housekeeping protein-coding genes interrogated with tissue and individual variations
Scientific Reports May 30, 2024

Housekeeping protein-coding genes are stably expressed genes in cells and tissues that are thought to be engaged in fundamental cellular bio ...

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潘明楷 博士
Neuronal population activity in the olivocerebellum encodes the frequency of essential tremor in mice and patients
Science Translational Medicine May 15, 2024

Essential tremor (ET) is the most prevalent movement disorder, characterized primarily by action tremor, an involuntary rhythmic movement wi ...

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胡哲銘 博士
Overcoming the nutritional immunity by engineering iron-scavenging bacteria for cancer therapy
Elife May 15, 2024

Certain bacteria demonstrate the ability to target and colonize the tumor microenvironment, a characteristic that positions them as innovati ...

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謝小燕 博士
A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
Cell Death & Differentiation May 07, 2024

Obesity is endemic to many developed countries. Overweight or obesity is associated with an increased risk of developing cancer. Dysfunction ...

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鈴木淳 博士
Genome-Wide Screening Approaches for Biochemical Reactions Independent of Cell Growth
Annual Review of Genomics and Human Genetics May 01, 2024

Genome-wide screening is a potent approach for comprehensively understanding the molecular mechanisms of biological phenomena. However, desp ...

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范盛娟 博士
Unsupervised Clustering Identified Clinically Relevant Metabolic Syndrome Endotypes in UK and Taiwan Biobanks
iScience Apr 25, 2024

Metabolic syndrome (MetS) is a collection of cardiovascular risk factors; however, the high prevalence and heterogeneity impede effective cl ...

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譚婉玉 博士
DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1
Cell Reports Mar 13, 2024

Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-canc ...

Years