楊泮池 博士Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer
Journal of Controlled Release Jun 01, 2020
Lung cancer is the primary cause of cancer-related death worldwide. 85%–90% of cases are non-small cell lung cancer (NSCLC) which char ......
羅傅倫 博士Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes
Acta Biomaterialia May 15, 2020
Abstract
Targeted antibodies and methoxy-PEGylated nanocarriers have gradually become a mainstream of cancer therapy. To increase the a ......
沈志陽 博士Tumorigenic and Metastatic Role of CD44−/low/CD24−/low Cells in Luminal Breast Cancer
Cancers May 14, 2020
Abstract
Cells with high CD44 but low CD24 expression (CD44high/CD24-/low) and high aldehyde dehydrogenase activity (ALDHbr) are widely ......
楊泮池 博士Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein
Journal of Medicinal Chemistry Mar 26, 2020
Drug resistance has been a major threat in cancer therapies that necessitates the development of new strategies to overcome this problem. We ......
李家偉 博士Targeting glycosylated PD-1 induces potent anti-tumor immunity
Cancer Research Mar 10, 2020
Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) immune checkpoints represent a ......
羅傅倫 博士Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex
ACS Nano Mar 06, 2020
Anti-polyethylene glycol (PEG) antibodies are present in many healthy individuals as well as in patients receiving polyethylene glycol-funct ......
楊泮池 博士Precision Management of Advanced Non–Small Cell Lung Cancer
Annual Review of Medicine Jan 27, 2020
The rapid evolution of treatment for advanced lung cancer is a story of how scientists have struggled to move from nonselective cytotoxic ch ......
沈志陽 博士A Functional Variant Near XCL1 Gene Improves Breast Cancer Survival via Promoting Cancer Immunity
International Journal of Cancer Jan 06, 2020
Most genome‐wide association studies (GWASs) identify genetic variants for breast cancer occurrence. In contrast, few are for recurrence and ......
張久瑗 博士Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44
Journal of Biomedical Science Jan 02, 2020
Background
Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granul ......
林文昌 博士miR-TV: an interactive microRNA Target Viewer for microRNA and target gene expression interrogation for human cancer studies
Database (Oxford) Jan 01, 2020
MicroRNAs (miRNAs) have been identified in many organisms, and they are essential for gene expression regulation in many critical cellular p ......
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