PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression

Journal of Biomedical Science Aug 02, 2021

Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the d ......

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沈志陽博士

Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: Applications to cardiovascular medicine.

J Adv Res. Jul 01, 2021

The human genome contains an enormous amount of informa-tion about human evolution, development, and medicine. To dis-cover the underlying g ......

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唐堂博士

Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position

Cells Jun 09, 2021

Autosomal recessive primary microcephaly (MCPH) is a complex neurodevelopmental disorder characterized by a small brain ......

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沈志陽博士

MiR-139 Modulates Cancer Stem Cell Function of Human Breast Cancer through Targeting CXCR4

Cancers May 25, 2021

Simple Summary The C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in various cancer stem/progenitor cells via ......

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李家偉博士

Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail

American Journal of Cancer Research May 15, 2021

The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Th ......

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楊泮池博士

Vorinostat combined with brigatinib overcomes acquired resistance in EGFR-C797S-mutated lung cancer

Cancer Letters Mar 26, 2021

The development of a new generation of tyrosine kinase inhibitors (TKIs) has improved the treatment response i ......

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李育儒博士

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

Nature Methods Mar 18, 2021

The architecture of chromatin regulates eukaryotic cell states by controlling transcription factor access to s ......

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鈴木淳博士

Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

Molecular Cell Mar 15, 2021

Phospholipid scrambling in dying cells promotes phosphatidylserine exposure, a critical process for efferocyto ......

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楊泮池博士

PINK1-mediated inhibition of EGFR dimerization and activation impedes EGFR-driven lung tumorigenesis

Cancer Research Feb 09, 2021

EGFR is established as a driver of lung cancer, yet the regulatory machinery underlying its oncogenic activity is not fully unders ......

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趙麗洋博士

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Journal of Biomedical Science Jan 05, 2021

Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early a ......

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