鄔哲源 博士

Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans

American Journal of Human Genetics Jan 11, 2018

Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottl ......

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鄔哲源 博士

A genome-wide association study links small-vessel ischemic stroke to autophagy

Scientific Reports Nov 09, 2017

Genome-wide association studies (GWAS) can serve as strong evidence in correlating biological pathways with human diseases. Although ischemi ......

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胡哲銘 博士

Targeting and Enrichment of Viral Pathogen by Cell Membrane Cloaked Magnetic Nanoparticles for Enhanced Detection

ACS Applied Materials & Interfaces Oct 31, 2017

Attachment to cellular surfaces is a major attribute among infectious pathogens for initiating disease pathogenesis. In viral infections, vi ......

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黃明經 博士

A proteome view of structural, functional, and taxonomic characteristics of major protein domain clusters

Scientific Reports Oct 27, 2017

Proteome-scale bioinformatics research is increasingly conducted as the number of completely sequenced genomes increases, but analysis of pr ......

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謝清河 博士

Subcellular Localization of Survivin Determines Its Function in Cardiomyocytes

Theranostics Oct 13, 2017

Rationale: Reducing cardiomyocyte death and enhancing their proliferation after myocardial infarction is perhaps the single largest challeng ......

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陳建璋 博士

Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus

Nature Communications Oct 10, 2017

Myocardial infarction is the leading cause of death worldwide. Restoration of blood flow rescues myocardium but also causes ischemia-reperfu ......

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楊瑞彬 博士

FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

Breast Cancer Research Oct 05, 2017

Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fuco ......

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楊瑞彬 博士

Guanylyl cyclase‐G is an alarm pheromone receptor in mice

EMBO Journal Sep 28, 2017

Many animals respond to threats by releasing alarm pheromones (APs) that warn conspecifics. In mice, detection of the AP 2‐sec‐butyl‐4,5‐dih ......

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謝清河 博士

Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1

Scientific Reports Sep 25, 2017

Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R sign ......

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鄔哲源 博士

A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

Nature Communications Sep 12, 2017

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some health ......

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