謝清河 博士

Inducing a Transient Increase in Blood–Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme

ACS Nano Dec 11, 2018

The blood–brain barrier (BBB) selectively controls the passage of endogenous and exogenous molecules between systemic circulation and ......

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楊瑞彬 博士

SCUBE1-enhanced bone morphogenetic protein signaling protects against renal ischemia-reperfusion injury

Biochimica et biophysica acta: molecular basis of disease Nov 07, 2018

We previously reported that the membrane-bound SCUBE1 (signal peptide-CUB-epithelial growth factor domain-containing protein 1) forms a comp ......

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趙麗洋 博士

Signal peptide peptidase promotes tumor progression via facilitating FKBP8 degradation

Oncogene Oct 22, 2018

Signal peptide peptidase (SPP) is an endoplasmic reticulum (ER)-resident aspartyl protease mediating intramembrane cleavage of type II trans ......

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胡哲銘 博士

725Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria

Acta Biomaterialia Oct 11, 2018

Amidst the ever-rising threat of antibiotics resistance, colistin, a decade-old antibiotic with lingering toxicity concern, is increasingl ......

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謝清河 博士

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

Circulation Oct 08, 2018

Background: The impact of gut microbiota on the regulation of host physiology has recently garnered considerable attention, particularly in ......

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張以承 博士

Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis

Journal of Diabetes Investigation Sep 01, 2018

Vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase highly expressed in mature adipocytes and released into the circu ......

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張以承 博士

Mitochondrial DNA associations with East Asian metabolic syndrome

Biochimica et Biophysica Acta (BBA) - Bioenergetics Sep 01, 2018

Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), as ......

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徐松錕 博士

Deletion of caveolin‐1 attenuates LPS/GalN‐induced acute liver injury in mice

Journal of Cellular and Molecular Medicine Aug 22, 2018

Acute hepatic injury caused by inflammatory liver disease is associated with high mortality. This study examined the role of caveolin‐1 (Cav ......

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趙麗洋 博士

Galectin-1 Restricts Vascular Smooth Muscle Cell Motility Via Modulating Adhesion Force and Focal Adhesion Dynamics

Scientific Reports Jul 31, 2018

Vascular smooth muscle cell (VSMC) migration play a key role in the development of intimal hyperplasia and atherosclerosis. Galectin-1 (Gal- ......

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謝清河 博士

The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling

Theranostics May 09, 2018

Rationale: Lapatinib (LAP) is a crucial alternative to trastuzumab upon the onset of drug resistance during treatment of metastatic human ep ......

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