Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell–Like Properties and Epithelial–Mesenchymal Transdifferentiation.

Cancer Res. Dec 15, 2010

Epithelial–mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of ......

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林文昌博士

dbDNV: a resource of duplicated gene nucleotide variants in human genome.

Nucleic Acids Res Nov 21, 2010

Gene duplications are scattered widely throughout the human genome. A single-base difference located in nearly identical duplicated segments ......

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周玉山博士

IGRhCellID: integrated genomic resources of human cell lines for identification.

Nucleic Acids Research Nov 04, 2010

Cell line identification is emerging as an essential method for every cell line user in research community to avoid using misidentified cell ......

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吳成文博士

EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF.

Cancer Res. Nov 01, 2010

MicroRNAs (miRNA) mediate distinct gene regulatory pathways triggered by epidermal growth factor receptor (EGFR) activation, which occurs co ......

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周玉山博士

Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma.

Hepatology Aug 31, 2010

Recurrent cancer genome aberrations are indicators of residing crucial cancer genes. Although recent advances in genomic technologies have l ......

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沈志陽博士

Diverse Associations between ESR1 Polymorphism and Breast Cancer Development and Progression.

Clinical Cancer Research Jun 22, 2010

To test the hypothesis that polymorphisms of ESR1, the gene encoding estrogen receptor α (ERα), are associated with susceptibili ......

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施修明博士

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.

J Cell Biol. Jun 21, 2010

Mitotic spindles play essential roles in chromosome congression and segregation during mitosis. Aurora A regulates spindle assembly in part ......

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羅傅倫博士

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling.

J Immunology Apr 30, 2010

Engagement of the TCR by antigenic peptides presented by the MHC activates specific T cells to control infections. Recent theoretical consid ......

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謝小燕博士

p53-Mediated transactivation of LIMK2b links actin dynamics to cell cycle checkpoint control.

Oncogene Mar 01, 2010

The p53 tumor suppressor protein is widely known for its role as a sequence-specific transcription factor that regulates the expression of s ......

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