The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Oncogene Dec 03, 2012
Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (R ......
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy.
Clin Cancer Res. Jul 18, 2012
Histone deacetylase inhibitors (HDACi) are actively explored as new-generation epigenetic drugs but have low efficacy in cancer monotherapy. ......
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
Oncogene. Jun 11, 2012
The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an end ......
TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.
EMBO Mol Med. May 15, 2012
Trop-2, a cell surface glycoprotein, contains both extracellular epidermal growth factor-like and thyroglobulin type-1 repeat domains. Low T ......