Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activity.
Oncogene. Jun 16, 2014
Heme oxygenase-1 (HO-1) is a heme-degrading enzyme anchored in the endoplasmic reticulum by a carboxyl-terminal transmembrane segment (TMS). ......
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.
Nat Commun. May 25, 2014
Cancer stem cells (CSCs) are a promising target for treating cancer, yet how CSC plasticity is maintained in vivo is unclear and is difficul ......
Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.
J Biol Chem. Apr 24, 2014
Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its import ......
Hypoxic mesenchymal stem cells engraft and ameliorate limb ischaemia in allogeneic recipients.
Cardiovasc Res. Feb 01, 2014
Local injection of stem cells or endothelial progenitors directly into the ischaemic tissue remains an option for the management of arterial ......
Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder.
Biomaterials. Jan 04, 2014
Early metastasis is one of the major causes of mortality among patient with lung cancer. The process of tumor metastasis involves a cascade ......