楊泮池 博士
Small-molecule, T315, Promotes CBL-dependent Degradation of EGFR via Y1045 Autophosphorylation.
Am J Respir Crit Care Med. Nov 19, 2015
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謝小燕 博士
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Nucl. Acids Res. Nov 03, 2015
Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response. Here, we present new evidence that hMp ......
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楊泮池 博士
MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.
Oncotarget. Nov 02, 2015
Melanoma differentiation-associated gene-9 (MDA-9)/Syntenin is a novel therapeutic target because it plays critical roles in cancer progress ......
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沈志陽 博士
Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer.
Oncotarget. Oct 23, 2015
Metastatic spread of cancer cells portends a poor prognosis and mortality for lung cancer patients. Hypoxia-inducible factor-1α (HIF-1 ......
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楊泮池 博士
Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.
Oncotarget. Oct 19, 2015
Dysfunction of the mitochondria is well-known for being associated with cancer progression. In the present study, we analyzed the mitochondr ......
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沈志陽 博士
Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study.
BMJ. Sep 23, 2015
OBJECTIVE:
To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cu ......
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洪士杰 博士
Allo-transplantation of Mesenchymal Stem Cells Attenuates Hepatic Injury through IL1Ra Dependent Macrophage Switch in a Mouse Model of Liver Disease.
J Hepatol. Aug 11, 2015
Autologous transplantation of mesenchymal stem cells (MSCs) reduces concanavalin A (Con A)-induced hepatic injury in mice. However, the mech ......
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沈志陽 博士
FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.
Hum Mol Genet. May 18, 2015
The association between breast cancer risk and genetic variants of fibroblast growth factor receptor 2 (FGFR2) has been identified and repea ......
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羅傅倫 博士
Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies.
Mol Cancer Ther. Apr 07, 2015
Polyethylene glycol (PEG) is attached to many peptides, proteins, liposomes and nanoparticles to reduce their immunogenicity and improve the ......
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楊泮池 博士
CXCL10/IP-10 is a Biomarker and Mediator for Kawasaki Disease.
Nat Commun. Mar 05, 2015
Anticancer therapies are often compromised by nonspecific effects and challenged by tumour environments' inherent physicochemical and bi ......
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