Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Nature communications Dec 22, 2016

Hypoxia is a major driving force of cancer invasion and metastasis. Here we show that death domain-associated protein (Daxx) acts to negativ ......

詳情

楊泮池博士

Remote Control of Light-Triggered Virotherapy

ACS Nano Nov 07, 2016

Clinical virotherapy has been successfully approved for use in cancer treatment by the U.S. Food and Drug Administration; however, a number ......

詳情

張久瑗博士

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner

Oncogene Nov 07, 2016

Tumor microenvironment (TME) plays an active role in promoting tumor progression. To further understand the communication between TME and tu ......

詳情

羅傅倫博士

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Analytical chemistry Oct 11, 2016

Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeu ......

詳情

洪士杰博士

Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Nature Communications Jun 16, 2016

Targeting tumour-initiating cells (TICs) would lead to new therapies to cure cancer. We previously demonstrated that TICs have the capacity ......

詳情

李玲慧博士

Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression

Oncotarget Jun 13, 2016

Development of colorectal cancer (CRC) involves sequential transformation of normal mucosal tissues into benign adenomas and then adenomas i ......

詳情

唐堂博士

Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis.

Cell Reports Mar 15, 2016

CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that ......

詳情

沈志陽博士

MicroRNA-30a increases tight junction protein expression to suppress the epithelial-mesenchymal transition and metastasis by targeting Slug in breast cancer.

Oncotarget Feb 24, 2016

The epithelial-to-mesenchymal (EMT) transition is a prerequisite for conferring metastatic potential during tumor progression. microRNA-30a ......

詳情