Efficacy and safety are fundamental prerequisites for anticancer drug development. In the present study, we explored the anti–colorect ......
The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the cons ......
Cellular metabolism of cancer cell is generally recognized to provide energy for facilitating tumor growth, but little is known about the ab ......
Overexpression of heme oxygenase-1 (HO-1), an endoplasmic reticulum-anchored enzyme, is observed in many cancers. HO-1 nuclear translocation ......
Introduction
The concept of immune checkpoint blockade has revolutionized anti-cancer strategies in nearly all cancer fields.1 Monoclonal ......
Mutations in many centriolar protein-encoding genes cause primary microcephaly. Using super-resolution and electron microscopy, we find that ......
Novel genes arising from random DNA sequences (de novo genes) have been suggested to be widespread in the genomes of different organisms. Ho ......
T lymphocytes are important mediators of adoptive immunity but the mechanism of T cell receptor (TCR) triggering remains uncertain. The inte ......
Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal ......
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