羅傅倫 博士

Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice

Pharmaceutics Dec 21, 2019

Pre-existing antibodies that bind polyethylene glycol are present in about 40% of healthy individuals. It is currently unknown if pre-existi ......

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周玉山 博士

Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma

Nucleic Acids Research Dec 19, 2019

Precise noncoding RNA (ncRNA)-based network prediction is necessary to reveal ncRNA functions and pathological mechanisms. Here, we establis ......

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周玉山 博士

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Nature Communications Dec 16, 2019

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide due to metastasis. Paraspeckle component 1 (PSPC1) upregulation h ......

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沈志陽 博士

The Causal Relationship of Circulating Triglycerides and Glycated Hemoglobin: A Mendelian Randomization Study

Journal of Clinical Endocrinology & Metabolism Nov 30, 2019


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林文昌 博士

Overlapping protein-coding genes in human genome and their coincidental expression in tissues

Scientific Reports Sep 16, 2019

The completion of human genome sequences and the advancement of next-generation sequencing technologies have engendered a clear understandin ......

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楊泮池 博士

4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin

European Journal of Medicinal Chemistry Aug 02, 2019

Developing new therapeutic strategies to overcome drug resistance of cancer cells is an ongoing endeavor. From among 2 million chemicals, we ......

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周玉山 博士

A New Switch for TGFβ in Cancer

Cancer Research Jul 12, 2019

The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and premalignant cancer cells, the TGFβ signaling pa ......

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羅傅倫 博士

Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer

Biomaterials Science Jun 28, 2019

For those patients with HER2-overexpressing breast cancer, treatment with PEGylated liposomal doxorubicin (PLD) is inefficacious due to the ......

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唐堂 博士

CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis

Scientific Reports Apr 15, 2019

Centrosomal protein 120 (CEP120) was originally identified as a daughter centriole-enriched protein that participates in centriole elongatio ......

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楊泮池 博士

A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure

Theranostics Feb 28, 2019

Rationale: The TNF-α pathway plays as a double-edged sword that simultaneously regulates cell apoptosis and proliferation. The dysregu ......

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