楊泮池 博士

Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response

Science Advances Apr 07, 2023

      Immune checkpoint inhibitors (ICIs) targeting PD-L1 immunotherapy are state-of-the-art treatments for advanced ......

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楊泮池 博士

PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway

EMBO Molecular Medicine Mar 28, 2023

      Particulate matter 2.5 (PM2.5) is a risk factor for lung cancer. In this study, we investigated the molecular ......

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羅傅倫 博士

Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines

ACS Nano Mar 16, 2023

      Nanomedicines and macromolecular drugs can induce hypersensitivity reactions (HSRs) with symptoms ranging from ......

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羅傅倫 博士

Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture

Journal of Controlled Release Jan 17, 2023

      Methoxy polyethylene glycol (mPEG) is attached to many proteins, peptides, nucleic acids and nanomedicines to ......

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李家偉 博士

Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion

Journal of medical virology Jan 07, 2023

      Patients with severe COVID-19 often suffer from lymphopenia, which is linked to T cell sequestration, cytokine ......

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