林文昌 博士

TEx-MST: tissue expression profiles of MANE select transcripts

Database(Oxford) Sep 28, 2022

      Recently, a new reference transcript dataset [Matched Annotation from the NCBI and EMBL-EBI (MANE) select] was ......

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謝小燕 博士

JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability

Cell Death & Disease Jul 18, 2022

      Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the s ......

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施修明 博士

Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth

Cellular and Molecular Life Sciences Jun 19, 2022

      Upregulation of death-domain-associated protein (Daxx) is strongly associated with diverse cancer types. Among ......

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張久瑗 博士

Patient-Derived Organoid Serves as a Platform for Personalized Chemotherapy in Advanced Colorectal Cancer Patients

Frontiers in Oncology Jun 01, 2022

      Background: Addition of oxaliplatin to adjuvant 5-FU has significantly improved the disease-free survival ......

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林文昌 博士

Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset

Scientific Reports Apr 28, 2022

      The discovery and quantification of mRNA transcripts using short-read next-generation sequencing (NGS) data is ......

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周玉山 博士

Prognostic comparative genes predict targets for sorafenib combination therapies in hepatocellular carcinoma

Comput Struct Biotechnol J Apr 20, 2022

      With the increasing incidence and mortality of human hepatocellular carcinoma (HCC) worldwide, revealing innov ......

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牟昀 博士

Development of a TNF-α-mediated Trojan Horse for Bacteria-based Cancer Therapy

Molecular Therapy Apr 19, 2022

      TNF-α is up-regulated in a chronic inflammatory environment, including tumors, and has been recognized a ......

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唐堂 博士

A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis

Journal of Biomedical Science Apr 01, 2022

    Background Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps includi ......

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牟昀 博士

Fragment-Directed Random Mutagenesis by the Reverse Kunkel Method

ACS Synthetic Biology Mar 24, 2022

      Two fundamentally different approaches are routinely used for protein engineering: user-defined mutagenesis an ......

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唐堂 博士

Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein

Frontiers in Cell and Developmental Biology Mar 02, 2022

      The centrosome is composed of a pair of centrioles and serves as the major microtubule-organizing center (MTOC ......

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