A hybrid mRNA vaccine induced broadly neutralizing antibodies against Omicron and other SARS-CoV-2 variants
Wuhan wild-type strain-based vaccines became almost ineffective against new SARS-CoV-2 variants. Academia Sinica mRNA Alpha team constructed a hybrid mRNA vaccine containing mutations of Omicron and Delta variants. When used as a booster in mice previously immunized with wild-type vaccine, the hybrid vaccine induced high titers of broadly neutralizing antibodies against all tested variants, as well as T cell responses against conserved T cell epitope. This hybrid vaccine also includes important mutation sites of Omicron BA.4/5, its effectiveness against the new dominant strains is being explored.
*The co-first authors, I-Jung Lee is a Ph.D. student of Graduate Institute of Microbiology, National Taiwan University, Cheng-Pu Sun is Project Research Manager, and Ping-Yi Wu is Senior Research Assistant of Institute of Biomedical Sciences, Academia Sinica.
*This study was conducted at the Institute of Biomedical Sciences and the Biomedical Translation Research Center, Academia Sinica.