Dr. Yang, Ruey-Bing (Ray)Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke.
J. Am Coll Cardiol., Jun 03, 2008This study investigates the potential application of plasma SCUBE1 [signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epiderma ......
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Dr. Chau, Lee-Young Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathway.
Biochim Biophys Acta., May 21, 2008The present study investigated the cellular mechanism underlying the degradation of heme oxygenase-1 (HO-1), an endoplasmic reticulum (ER ......
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Dr. Fann, Cathy S.-J. Genome-wide copy number analysis using copy number inferring tool (CNIT) and DNA pooling.
Hum Mutat., May 09, 2008Copy number variation (CNV) has become an important genomic structure element in the human population, and some CNVs are related to speci ......
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Dr. Lin, Wen-chang Designating eukaryotic orthology via processed transcription units.
Nucleic Acids Research, Apr 29, 2008Orthology is a widely used concept in comparative and evolutionary genomics. In addition to prokaryotic orthology, delineating eukaryotic ......
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Dr. Yao, Wen-Hsuang GenoWatch: a disease gene mining browser for association study.
Nucleic Acids Research, Apr 25, 2008A human gene association study often involves several genomic markers such as single nucleotide polymorphisms (SNPs) or short tandem repe ......
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Dr. Chern, Yijuang Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes.
J. of Neuroscience, Mar 26, 2008Huntington's disease (HD) is a hereditary neurological disease caused by expended CAG repeats in the HD gene, which codes for a prote ......
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Dr. Lim, Carmay Mononuclear versus Binuclear Metal-Binding Sites: Metal-Binding Affinity and Selectivity from PDB Survey and DFT/CDM Calculations.
J. Am. Chem. Soc., Feb 28, 2008Binuclear metal centers in metalloenzymes are involved in a number of hydrolytic, hydration, isomerization, and redox processes. Despite ......
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Dr. Yang, Pan-Chyr Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model.
Nano Lett., Feb 13, 2008Carbon nanotubes are a nanomaterial that is extensively used in industry. The potential health risk of chronic carbon nanotubes exposure ......
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Dr. Yang, Ruey-Bing (Ray)Disruption of Guanylyl Cyclase-G Protects against Acute Renal Injury.
J. of the Am. Soc. of Nephrology., Jan 16, 2008The membrane forms of guanylyl cyclase (GC) serve as cell-surface receptors that synthesize the second messenger cGMP, which mediates div ......
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Dr. Chen, Yuan-Tsong Prospective Study of Warfarin Dosage Requirements Based on CYP2C9 and VKORC1 Genotypes.
Clinical Pharmacology and Therapeutics., Jan 09, 2008Polymorphisms in CYPyp2C9 and VKORorC1 have been shown to be associated with warfarin dose requirements and could be used to predict warf ......
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