Dr. Liu, Fu-Tong Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice
PNAS, Sep 12, 2011The breakdown of triglycerides, or lipolysis, is a tightly controlled process that regulates fat mobilization in accord with an animal's ......
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Dr. Chen, Chinpan Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation
Nucl. Acids Res., Sep 08, 2011Trichomonas vaginalis Myb3 transcription factor (tvMyb3) recognizes the MRE-1 promoter sequence and regulates ap65-1 gene, which encodes a h ......
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Dr. Lee, Eminy H.Y. Laminin-β1 Impairs Spatial Learning through Inhibition of ERK/MAPK and SGK1 Signaling.
Neuropsychopharmacology, Aug 17, 2011Laminin is a major structural element of the basal lamina consisting of an α-chain, a β-chain, and a γ-chain arranged in a ......
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Dr. Yang, Pan-Chyr The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1.
J Clin Invest., Aug 01, 2011Metastasis is a predominant cause of death in patients with cancer. It is a complex multistep process that needs to be better understood if ......
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Dr. Huang, Tai-huang Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis
Nucl. Acids Res., Jul 19, 2011Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least three Myb-like transcriptional factors (tvMyb1, t ......
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Dr. Pan, Wen-Harn A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes.
Diabetes, Jul 19, 2011The plasma adiponectin level, a potential upstream and internal facet of metabolic and cardiovascular diseases, has a reasonably high herita ......
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Dr. Chern, Yijuang Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington』s disease.
JCB, Jul 18, 2011Adenosine monophosphate–activated protein kinase (AMPK) is a major energy sensor that maintains cellular energy homeostasis. Huntingto ......
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Dr. Wu, Jer-Yuarn Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Nature Genetics, May 15, 2011We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of e ......
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Dr. Shih, Hsiu-Ming Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation.
Molecular Cell, May 08, 2011Small ubiquitin-like modifier (SUMO) conjugation and interaction are increasingly associated with various cellular processes. However, littl ......
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Dr. Tarn, Woan-Yuh RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing.
JCB., May 02, 2011Alternative splicing contributes largely to cell differentiation and functional specification. We previously reported that the RNA-binding p ......
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