2012 Highlights

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Dr. Lin , Yi-Ling
Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity.
PLoS Pathogens Jun 28, 2012

Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN). We found that activation ...

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Dr. Huang , Yi-Shuian
NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
Nucleic Acids Res. Jun 22, 2012

Cytoplasmic polyadenylation element-binding protein (CPEB)3 is a nucleocytoplasm-shuttling RNA-binding protein and predominantly resides in ...

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Dr. Huang , Yi-Shuian
Calpain 2 activated through the NMDA receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
MCB Jun 18, 2012

Long-term memory requires the activity-dependent reorganization of synaptic proteome to modulate synaptic efficacy and consequently consolid ...

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Dr. Chau , Lee-Young
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
Oncogene. Jun 11, 2012

The TRC8 gene, which was previously shown to be disrupted by a 3;8 chromosomal translocation in hereditary kidney cancer, encodes for an end ...

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Dr. Lim , Carmay
DR_bind: a web server for predicting DNA-binding residues from the protein structure based on electrostatics, evolution and geometry.
Nucl. Acids Res May 31, 2012

DR_bind is a web server that automatically predicts DNA-binding residues, given the respective protein structure based on (i) electrostatics ...

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Dr. Chern , Yijuang
Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.
Cell Mol Life Sci. May 25, 2012

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin ( ...

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Dr. Chen , Yuan-Tsong
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
Nat Genet. May 25, 2012

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wi ...

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Dr. Yao , Wen-Hsuang
VarioWatch: providing large-scale and comprehensive annotations on human genomic variants in the next generation sequencing era.
Nucleic Acids Res. May 22, 2012

VarioWatch has been vastly improved since its former publication GenoWatch in the 2008 Web Server Issue. It is now at least 10 000-ti ...

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Dr. Lin , Teng-Nan
Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders.
Mol Neurobiol. May 21, 2012

As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzhei ...

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Dr. Kannagi , Reiji
Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial–mesenchymal transition
PNAS May 15, 2012

Sialyl Lewis x (sLex) and sialyl Lewis a (sLea)   glycans are expressed on highly metastatic colon cancer cells. They   promote ex ...

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