2014 Highlights

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Dr. Chang , Chen
White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling.
Brain Struct Funct. Apr 26, 2014

White matter tracts are important for the trafficking of neural progenitor cells (NPCs) in both normal and pathological conditions, but the ...

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Dr. Lin , Teng-Nan
Novel Link of Anti-apoptotic ATF3 with Pro-apoptotic CTMP in the Ischemic Brain.
Mol Neurobiol. Apr 26, 2014

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor with diverse functions under disease states in multiple ce ...

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Dr. Shieh , Sheau-Yann
Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.
J Biol Chem. Apr 24, 2014

Human Mps1 (hMps1/TTK) is a mitotic checkpoint kinase responsible for sensing the unattached and tensionless kinetochore. Despite its import ...

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Dr. Chern , Yijuang
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.
Hum Mol Genet. Apr 03, 2014

Neuroinflammation is a common feature of many neurodegenerative diseases, including Huntington's disease (HD). HD is an autosomal dominant g ...

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Dr. Lee , Yungling Leo
Pathway From Central Obesity to Childhood Asthma: Physical Fitness and Sedentary Time Are Leading Factors.
Am J Respir Crit Care Med. Mar 26, 2014

Rationale: Available prospective studies of obesity and asthma have used only body mass index (BMI) as an indicator for adiposity; studies u ...

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Dr. Lee , Eminy H.Y.
STAT1 Negatively Regulates Spatial Memory Formation and Mediates the Memory-Impairing Effect of Aβ.
Neuropsychopharmacology Feb 15, 2014

Signal transducer and activator of transcription-1 (STAT1) plays an important role in inflammation and the innate immune response, but its r ...

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Dr. Lim , Carmay
Evolution of eukaryotic ion channels: Principles underlying the conversion of Ca2+-selective to Na+-selective channels.
J Am Chem Soc. Feb 11, 2014

Ion selectivity of four-domain voltage-gated Ca2+ and Na+ channels, which is controlled by the selectivity filter (the narrowest region of a ...

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Dr. Hung , Shih Chieh
Hypoxic mesenchymal stem cells engraft and ameliorate limb ischaemia in allogeneic recipients.
Cardiovasc Res. Feb 01, 2014

Local injection of stem cells or endothelial progenitors directly into the ischaemic tissue remains an option for the management of arterial ...

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Dr. Lin , Yi-Ling
Surfactant-modified nanoclay exhibits an antiviral activity with high potency and broad spectrum.
J Virol. Jan 29, 2014

The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defense agai ...

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Dr. Lim , Carmay
Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations.
Nat Commun. Jan 24, 2014

IgE mediates hypersensitivity reactions responsible for most allergic diseases, which affect 20-40% of the population in developed countries ...

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